InnateDB Protein
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IDBP-102638.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PGLYRP3
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Protein Name
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peptidoglycan recognition protein 3
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000290722
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InnateDB Gene
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IDBG-102636 (PGLYRP3)
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Protein Structure
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Function |
Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram- negative bacteria, and has bacteriostatic activity towards Gram- negative bacteria. Plays a role in innate immunity. {ECO:0000269PubMed:16354652}.
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Subcellular Localization |
Secreted {ECO:0000269PubMed:16354652}.
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Disease Associations |
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Tissue Specificity |
Detected in skin epidermis, eccrine sweat glands and ducts, ciliary body epithelial cells of the eye, in small intestine, colon, stomach and in mature epithelial cells of the tongue (at protein level). Highly expressed in skin and esophagus, expressed also in tonsils and thymus and to a much lesser extent in the stomach, descending colon, rectum and brain. {ECO:0000269PubMed:11461926, ECO:0000269PubMed:16354652}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0002221
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pattern recognition receptor signaling pathway
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GO:0009253
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peptidoglycan catabolic process
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GO:0016045
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detection of bacterium
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GO:0032689
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negative regulation of interferon-gamma production
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GO:0032827
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negative regulation of natural killer cell differentiation involved in immune response
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GO:0044117
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growth of symbiont in host
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GO:0045087
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innate immune response (InnateDB)
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GO:0050830
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defense response to Gram-positive bacterium
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Cellular Component |
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PDB ID |
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InterPro |
IPR002502
N-acetylmuramoyl-L-alanine amidase domain
IPR006619
Peptidoglycan recognition protein family domain, metazoa/bacteria
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PFAM |
PF01510
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PRINTS |
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PIRSF |
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SMART |
SM00644
SM00701
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TIGRFAMs |
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Modification |
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SwissProt |
Q96LB9
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PhosphoSite |
PhosphoSite-Q96LB9
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
114771
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UniGene |
Hs.348266
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RefSeq |
NP_443123
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HUGO |
HGNC:30014
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OMIM |
608197
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CCDS |
CCDS1035
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HPRD |
16297
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IMGT |
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EMBL |
AL161636
AL591704
AY035376
BC069741
BC069798
BC069801
BC128114
BC128115
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GenPept |
AAH69741
AAH69798
AAH69801
AAI28115
AAI28116
AAK72484
CAI19491
CAI19556
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