InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CREB3L4

Summary

InnateDB Gene

IDBG-102825.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CREB3L4

Gene Name

cAMP responsive element binding protein 3-like 4

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000143578

Encoded Proteins

IDBP-102827

cAMP responsive element binding protein 3-like 4

IDBP-102829

cAMP responsive element binding protein 3-like 4

IDBP-102831

cAMP responsive element binding protein 3-like 4

IDBP-102833

cAMP responsive element binding protein 3-like 4

IDBP-102835

cAMP responsive element binding protein 3-like 4

IDBP-388739

cAMP responsive element binding protein 3-like 4

IDBP-388745

cAMP responsive element binding protein 3-like 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a CREB (cAMP responsive element binding) protein with a transmembrane domain which localizes it to the ER membrane. The encoded protein is a transcriptional activator which contains a dimerization domain, and this protein may function in a number of processing pathways including protein processing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:153967534-153974363

Strand

Forward strand

Band

q21.3

Transcripts

ENST00000368607	ENSP00000357596
ENST00000271889	ENSP00000271889
ENST00000368603	ENSP00000357592
ENST00000368601	ENSP00000357590
ENST00000368600	ENSP00000357589
ENST00000449724	ENSP00000391847
ENST00000431292	ENSP00000402308
ENST00000477617
ENST00000461688
ENST00000479010
ENST00000492729
ENST00000473340
ENST00000468845

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001228	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006986	response to unfolded protein
GO:0007283	spermatogenesis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0000139	Golgi membrane
GO:0005634	nucleus
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000027938

View Gene Order

ENSBTAG00000014692

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa05215

Prostate cancer pathway

hsa04916

Melanogenesis pathway

hsa05016

Huntington's disease pathway

hsa04962

Vasopressin-regulated water reabsorption pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.372924

RefSeq

NM_001255978 NM_001255979 NM_001255980 NM_001255981 NM_130898 XM_006711172

HUGO

OMIM

CCDS

CCDS1056 CCDS58029

HPRD

06323

IMGT

EMBL

GenPept

RNA Seq Atlas