Homo sapiens Gene: CREB3L4
Summary
InnateDB Gene IDBG-102825.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CREB3L4
Gene Name cAMP responsive element binding protein 3-like 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000143578
Encoded Proteins
cAMP responsive element binding protein 3-like 4
cAMP responsive element binding protein 3-like 4
cAMP responsive element binding protein 3-like 4
cAMP responsive element binding protein 3-like 4
cAMP responsive element binding protein 3-like 4
cAMP responsive element binding protein 3-like 4
cAMP responsive element binding protein 3-like 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a CREB (cAMP responsive element binding) protein with a transmembrane domain which localizes it to the ER membrane. The encoded protein is a transcriptional activator which contains a dimerization domain, and this protein may function in a number of processing pathways including protein processing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:153967534-153974363
Strand Forward strand
Band q21.3
Transcripts
ENST00000368607 ENSP00000357596
ENST00000271889 ENSP00000271889
ENST00000368603 ENSP00000357592
ENST00000368601 ENSP00000357590
ENST00000368600 ENSP00000357589
ENST00000449724 ENSP00000391847
ENST00000431292 ENSP00000402308
ENST00000477617
ENST00000461688
ENST00000479010
ENST00000492729
ENST00000473340
ENST00000468845
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006986 response to unfolded protein
GO:0007283 spermatogenesis
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0000139 Golgi membrane
GO:0005634 nucleus
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Melanogenesis pathway
Vasopressin-regulated water reabsorption pathway
Huntington's disease pathway
Prostate cancer pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.372924
RefSeq NM_001255978 NM_001255979 NM_001255980 NM_001255981 NM_130898 XM_006711172
HUGO
OMIM
CCDS CCDS1056 CCDS58029
HPRD 06323
IMGT
EMBL
GenPept
RNA Seq Atlas