Version 5.4
Homo sapiens Gene: CKS1B
Summary
InnateDB Gene IDBG-103022.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CKS1B
Gene Name CDC28 protein kinase regulatory subunit 1B
Synonyms CKS1; ckshs1; PNAS-16; PNAS-18
Species Homo sapiens
Ensembl Gene ENSG00000173207
Encoded Proteins
IDBP-103024
CDC28 protein kinase regulatory subunit 1B
IDBP-103026
CDC28 protein kinase regulatory subunit 1B
IDBP-103028
CDC28 protein kinase regulatory subunit 1B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary CKS1B protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS1B mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects a specialized role for the encoded protein. At least two transcript variants have been identified for this gene, and it appears that only one of them encodes a protein. [provided by RefSeq, Sep 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:154974653-154979249
Strand Forward strand
Band q21.3
Transcripts
ENST00000368439 ENSP00000357424
ENST00000308987 ENSP00000311083
ENST00000368436 ENSP00000357421
ENST00000477676
ENST00000474215
ENST00000473344
ENST00000471245
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 42 [view]
Protein-Protein 41 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016301 kinase activity
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity
Biological Process
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0007049 cell cycle
GO:0008283 cell proliferation
GO:0016310 phosphorylation
GO:0045859 regulation of protein kinase activity
GO:0051301 cell division
Cellular Component
GO:0005654 nucleoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028044
View Gene Order
ENSBTAG00000024476
Not yet available
Pathways
NETPATH
REACTOME
REACT_9003
SCF(Skp2)-mediated degradation of p27/p21 pathway
REACT_9029
Cyclin A:Cdk2-associated events at S phase entry pathway
REACT_1574
Cyclin E associated events during G1/S transition pathway
REACT_821
Cyclin D associated events in G1 pathway
REACT_1590
G1 Phase pathway
REACT_21267
Mitotic G1-G1/S phases pathway
REACT_899
S Phase pathway
REACT_1783
G1/S Transition pathway
REACT_115566
Cell Cycle pathway
REACT_152
Cell Cycle, Mitotic pathway
KEGG
hsa05222
Small cell lung cancer pathway
hsa05200
Pathways in cancer pathway
INOH
PID NCI
foxm1pathway
FOXM1 transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.374378 Hs.660781 Hs.667409 Hs.672502
RefSeq NM_001826
HUGO
OMIM
CCDS CCDS1077
HPRD 00299
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca