Homo sapiens Gene: CKS1B
Summary
InnateDB Gene IDBG-103022.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CKS1B
Gene Name CDC28 protein kinase regulatory subunit 1B
Synonyms CKS1; ckshs1; PNAS-16; PNAS-18;
Species Homo sapiens
Ensembl Gene ENSG00000173207
Encoded Proteins
CDC28 protein kinase regulatory subunit 1B
CDC28 protein kinase regulatory subunit 1B
CDC28 protein kinase regulatory subunit 1B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary CKS1B protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS1B mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects a specialized role for the encoded protein. At least two transcript variants have been identified for this gene, and it appears that only one of them encodes a protein. [provided by RefSeq, Sep 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:154974653-154979249
Strand Forward strand
Band q21.3
Transcripts
ENST00000368439 ENSP00000357424
ENST00000308987 ENSP00000311083
ENST00000368436 ENSP00000357421
ENST00000477676
ENST00000474215
ENST00000473344
ENST00000471245
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 42 [view]
Protein-Protein 41 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016301 kinase activity
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity
Biological Process
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0007049 cell cycle
GO:0008283 cell proliferation
GO:0016310 phosphorylation
GO:0045859 regulation of protein kinase activity
GO:0051301 cell division
Cellular Component
GO:0005654 nucleoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
G1 Phase pathway
Mitotic G1-G1/S phases pathway
S Phase pathway
Cyclin D associated events in G1 pathway
G1/S Transition pathway
Cell Cycle pathway
Cyclin E associated events during G1/S transition pathway
Cell Cycle, Mitotic pathway
SCF(Skp2)-mediated degradation of p27/p21 pathway
Cyclin A:Cdk2-associated events at S phase entry pathway
KEGG
Pathways in cancer pathway
Small cell lung cancer pathway
INOH
PID BIOCARTA
Regulation of p27 phosphorylation during cell cycle progression [Biocarta view]
PID NCI
FOXM1 transcription factor network
Cross-References
SwissProt P61024
TrEMBL D3DV79 Q5T178 Q5T179 Q9BZU3
UniProt Splice Variant
Entrez Gene 1163
UniGene Hs.374378 Hs.660781 Hs.667409 Hs.672502
RefSeq NM_001826
HUGO HGNC:19083
OMIM 116900
CCDS CCDS1077
HPRD
IMGT
EMBL AF274941 AF274943 AF279897 AK311769 AL451085 BC007751 BC015629 BC070319 BC070320 BT007196 CH471121 X54941
GenPept AAH07751 AAH15629 AAH70319 AAH70320 AAK07518 AAK07520 AAK07553 AAP35860 BAG34712 CAA38702 EAW53160 EAW53161 EAW53162 EAW53163 EAW53164 EAW53165 EAW53166
RNA Seq Atlas 1163