Version 5.4
Homo sapiens Gene: PACSIN2
Summary
InnateDB Gene IDBG-10313.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PACSIN2
Gene Name protein kinase C and casein kinase substrate in neurons 2
Synonyms SDPII
Species Homo sapiens
Ensembl Gene ENSG00000100266
Encoded Proteins
IDBP-10315
protein kinase C and casein kinase substrate in neurons 2
IDBP-10317
protein kinase C and casein kinase substrate in neurons 2
IDBP-293004
protein kinase C and casein kinase substrate in neurons 2
IDBP-293005
protein kinase C and casein kinase substrate in neurons 2
IDBP-293006
protein kinase C and casein kinase substrate in neurons 2
IDBP-379098
protein kinase C and casein kinase substrate in neurons 2
IDBP-379101
protein kinase C and casein kinase substrate in neurons 2
IDBP-379105
protein kinase C and casein kinase substrate in neurons 2
IDBP-379108
protein kinase C and casein kinase substrate in neurons 2
IDBP-379110
protein kinase C and casein kinase substrate in neurons 2
IDBP-484318
protein kinase C and casein kinase substrate in neurons 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the protein kinase C and casein kinase substrate in neurons family. The encoded protein is involved in linking the actin cytoskeleton with vesicle formation by regulating tubulin polymerization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:42835412-43015145
Strand Reverse strand
Band q13.2
Transcripts
ENST00000263246 ENSP00000263246
ENST00000337959 ENSP00000338379
ENST00000407585 ENSP00000385952
ENST00000403744 ENSP00000385372
ENST00000402229 ENSP00000385040
ENST00000453643 ENSP00000398573
ENST00000422336 ENSP00000403435
ENST00000418133 ENSP00000396816
ENST00000445706 ENSP00000406767
ENST00000453079 ENSP00000399953
ENST00000507586 ENSP00000422788
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 35 [view]
Protein-Protein 35 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005515 protein binding
GO:0008092 cytoskeletal protein binding
GO:0008289 lipid binding
GO:0042802 identical protein binding
GO:0070300 phosphatidic acid binding
Biological Process
GO:0030036 actin cytoskeleton organization
GO:0036010 protein localization to endosome
GO:0045806 negative regulation of endocytosis
GO:0048858 cell projection morphogenesis
GO:0070836 caveola assembly
GO:0072584 caveolin-mediated endocytosis
GO:0097320 membrane tubulation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005769 early endosome
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005901 caveola
GO:0005911 cell-cell junction
GO:0019898 extrinsic component of membrane
GO:0030659 cytoplasmic vesicle membrane
GO:0032587 ruffle membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0055038 recycling endosome membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000016664
View Gene Order
ENSBTAG00000019290
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F8WC50
UniProt Splice Variant
Entrez Gene 11252
UniGene Hs.162877
RefSeq NM_001184970 NM_001184971 NM_007229 XM_005261319 XM_006724117 XM_006724118 XM_006724119 XM_006724120
HUGO HGNC:8571
OMIM 604960
CCDS CCDS43023 CCDS54536
HPRD 05390
IMGT
EMBL AL022476 AL049758
GenPept
RNA Seq Atlas 11252

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca