Homo sapiens Gene: RNPS1
Summary
InnateDB Gene IDBG-10321.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RNPS1
Gene Name RNA binding protein S1, serine-rich domain
Synonyms E5.1;
Species Homo sapiens
Ensembl Gene ENSG00000205937
Encoded Proteins
RNA binding protein S1, serine-rich domain
RNA binding protein S1, serine-rich domain
RNA binding protein S1, serine-rich domain
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. This protein contains many serine residues. Two splice variants have been found for this gene; both variants encode the same protein. [provided by RefSeq, Jul 2008]
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. This protein contains many serine residues. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:2253116-2268412
Strand Reverse strand
Band p13.3
Transcripts
ENST00000320225 ENSP00000315859
ENST00000301730 ENSP00000301730
ENST00000397086 ENSP00000380275
ENST00000568631 ENSP00000457820
ENST00000565678 ENSP00000457723
ENST00000566397 ENSP00000455379
ENST00000564822 ENSP00000456283
ENST00000567147 ENSP00000454513
ENST00000566783
ENST00000561518 ENSP00000454461
ENST00000570051
ENST00000564764 ENSP00000457378
ENST00000565589 ENSP00000457338
ENST00000565870 ENSP00000457110
ENST00000566180 ENSP00000457618
ENST00000565333 ENSP00000454867
ENST00000563857
ENST00000562205
ENST00000561718 ENSP00000455306
ENST00000562690 ENSP00000457296
ENST00000564311 ENSP00000455013
ENST00000566458 ENSP00000456352
ENST00000565243
ENST00000569709 ENSP00000455195
ENST00000564601 ENSP00000457690
ENST00000569598 ENSP00000457987
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 145 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 145 [view]
Protein-Protein 142 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003730 mRNA 3'-UTR binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000381 regulation of alternative mRNA splicing, via spliceosome
GO:0000398 mRNA splicing, via spliceosome
GO:0006351 transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006369 termination of RNA polymerase II transcription
GO:0006406 mRNA export from nucleus
GO:0008380 RNA splicing
GO:0010467 gene expression
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0031124 mRNA 3'-end processing
GO:0043065 positive regulation of apoptotic process
GO:0048025 negative regulation of mRNA splicing, via spliceosome
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016607 nuclear speck
GO:0035145 exon-exon junction complex
GO:0061574 ASAP complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Transport of Mature mRNA derived from an Intron-Containing Transcript pathway
mRNA 3'-end processing pathway
Nonsense-Mediated Decay (NMD) pathway
RNA Polymerase II Transcription Termination pathway
Processing of Capped Intron-Containing Pre-mRNA pathway
RNA Polymerase II Transcription pathway
Transport of Mature Transcript to Cytoplasm pathway
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) pathway
mRNA Splicing pathway
Cleavage of Growing Transcript in the Termination Region pathway
Gene Expression pathway
mRNA Splicing - Major Pathway pathway
KEGG
RNA transport pathway
mRNA surveillance pathway pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.355643 Hs.614625 Hs.684080 Hs.733012 Hs.736362
RefSeq NM_001286625 NM_001286626 NM_001286627 NM_006711 NM_080594
HUGO
OMIM
CCDS CCDS10465 CCDS66907 CCDS73811
HPRD 07341
IMGT
EMBL
GenPept
RNA Seq Atlas