InnateDB: Systems Biology of the Innate Immune Response

This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. This protein contains many serine residues. Two splice variants have been found for this gene; both variants encode the same protein. [provided by RefSeq, Jul 2008]
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. This protein contains many serine residues. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:2253116-2268412

Strand

Reverse strand

Band

p13.3

Transcripts

ENST00000320225	ENSP00000315859
ENST00000301730	ENSP00000301730
ENST00000397086	ENSP00000380275
ENST00000568631	ENSP00000457820
ENST00000565678	ENSP00000457723
ENST00000566397	ENSP00000455379
ENST00000564822	ENSP00000456283
ENST00000567147	ENSP00000454513
ENST00000566783
ENST00000561518	ENSP00000454461
ENST00000570051
ENST00000564764	ENSP00000457378
ENST00000565589	ENSP00000457338
ENST00000565870	ENSP00000457110
ENST00000566180	ENSP00000457618
ENST00000565333	ENSP00000454867
ENST00000563857
ENST00000562205
ENST00000561718	ENSP00000455306
ENST00000562690	ENSP00000457296
ENST00000564311	ENSP00000455013
ENST00000566458	ENSP00000456352
ENST00000565243
ENST00000569709	ENSP00000455195
ENST00000564601	ENSP00000457690
ENST00000569598	ENSP00000457987

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 145 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	145 [view]
Protein-Protein	142 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003730	mRNA 3'-UTR binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000381	regulation of alternative mRNA splicing, via spliceosome
GO:0000398	mRNA splicing, via spliceosome
GO:0006351	transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006369	termination of RNA polymerase II transcription
GO:0006406	mRNA export from nucleus
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0031124	mRNA 3'-end processing
GO:0043065	positive regulation of apoptotic process
GO:0048025	negative regulation of mRNA splicing, via spliceosome

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016607	nuclear speck
GO:0035145	exon-exon junction complex
GO:0061574	ASAP complex