Homo sapiens Gene: SMG5
Summary
InnateDB Gene IDBG-103447.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SMG5
Gene Name smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans)
Synonyms EST1B; LPTS-RP1; LPTSRP1; SMG-5;
Species Homo sapiens
Ensembl Gene ENSG00000198952
Encoded Proteins
smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary SMG5 is involved in nonsense-mediated mRNA decay (Ohnishi et al., 2003 [PubMed 14636577]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:156249224-156282825
Strand Reverse strand
Band q22
Transcripts
ENST00000361813 ENSP00000355261
ENST00000476954
ENST00000473643
ENST00000468993
ENST00000489907
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0051721 protein phosphatase 2A binding
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006406 mRNA export from nucleus
GO:0010467 gene expression
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0035303 regulation of dephosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Nonsense-Mediated Decay (NMD) pathway
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) pathway
Gene Expression pathway
KEGG
mRNA surveillance pathway pathway
INOH
PID BIOCARTA
PID NCI
Signaling events mediated by HDAC Class I
Regulation of Telomerase
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.516837
RefSeq NM_015327 XM_006711248
HUGO
OMIM
CCDS CCDS1137
HPRD 16869
IMGT
EMBL
GenPept
RNA Seq Atlas