Version 5.4
Homo sapiens Gene: NES
Summary
InnateDB Gene IDBG-103577.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NES
Gene Name nestin
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000132688
Encoded Proteins
IDBP-103579
nestin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the intermediate filament protein family and is expressed primarily in nerve cells. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:156668763-156677397
Strand Reverse strand
Band q23.1
Transcripts
ENST00000368223 ENSP00000357206
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005198 structural molecule activity
GO:0019215 intermediate filament binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0007399 nervous system development
GO:0007417 central nervous system development
GO:0007420 brain development
GO:0030844 positive regulation of intermediate filament depolymerization
GO:0031076 embryonic camera-type eye development
GO:0032091 negative regulation of protein binding
GO:0043086 negative regulation of catalytic activity
GO:0043524 negative regulation of neuron apoptotic process
GO:0048858 cell projection morphogenesis
GO:0072089 stem cell proliferation
GO:2000179 positive regulation of neural precursor cell proliferation
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005882 intermediate filament
GO:0045111 intermediate filament cytoskeleton
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000004891
View Gene Order
ENSBTAG00000015794
Not yet available
Cross-References
SwissProt P48681
TrEMBL Q2YDX4
UniProt Splice Variant
Entrez Gene 10763
UniGene Hs.527971
RefSeq NM_006617
HUGO HGNC:7756
OMIM 600915
CCDS CCDS1151
HPRD
IMGT
EMBL AB073350 AF004335 AL590666 BC108285 X65964
GenPept AAB64426 AAI08286 BAE45713 CAA46780 CAI16338
RNA Seq Atlas 10763

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca