Version 5.4
Homo sapiens Protein: NES
Summary
InnateDB Protein IDBP-103579.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NES
Protein Name nestin
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000357206
InnateDB Gene IDBG-103577 (NES)
Protein Structure
UniProt Annotation
Function Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity CNS stem cells.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005198 structural molecule activity
GO:0019215 intermediate filament binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0007399 nervous system development
GO:0007417 central nervous system development
GO:0007420 brain development
GO:0030844 positive regulation of intermediate filament depolymerization
GO:0031076 embryonic camera-type eye development
GO:0032091 negative regulation of protein binding
GO:0043086 negative regulation of catalytic activity
GO:0043524 negative regulation of neuron apoptotic process
GO:0048858 cell projection morphogenesis
GO:0072089 stem cell proliferation
GO:2000179 positive regulation of neural precursor cell proliferation
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005882 intermediate filament
GO:0045111 intermediate filament cytoskeleton
Protein Structure and Domains
PDB ID
InterPro IPR001664 Intermediate filament protein
PFAM PF00038
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P48681
PhosphoSite PhosphoSite-P48681
TrEMBL Q2YDX4
UniProt Splice Variant
Entrez Gene 10763
UniGene Hs.527971
RefSeq NP_006608
HUGO HGNC:7756
OMIM 600915
CCDS CCDS1151
HPRD 09020
IMGT
EMBL AB073350 AF004335 AL590666 BC108285 X65964
GenPept AAB64426 AAI08286 BAE45713 CAA46780 CAI16338

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca