InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CRABP2

Summary

InnateDB Gene

IDBG-103584.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CRABP2

Gene Name

cellular retinoic acid binding protein 2

Synonyms

CRABP-II; RBP6;

Species

Homo sapiens

Ensembl Gene

ENSG00000143320

Encoded Proteins

IDBP-103586

cellular retinoic acid binding protein 2

IDBP-103588

cellular retinoic acid binding protein 2

IDBP-103590

cellular retinoic acid binding protein 2

IDBP-807167

cellular retinoic acid binding protein 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the retinoic acid (RA, a form of vitamin A) binding protein family and lipocalin/cytosolic fatty-acid binding protein family. The protein is a cytosol-to-nuclear shuttling protein, which facilitates RA binding to its cognate receptor complex and transfer to the nucleus. It is involved in the retinoid signaling pathway, and is associated with increased circulating low-density lipoprotein cholesterol. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:156699606-156705816

Strand

Reverse strand

Band

q23.1

Transcripts

ENST00000368222	ENSP00000357205
ENST00000368221	ENSP00000357204
ENST00000368220	ENSP00000357203
ENST00000621784	ENSP00000482841

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001972	retinoic acid binding
GO:0005215	transporter activity
GO:0005501	retinoid binding
GO:0016918	retinal binding
GO:0019841	retinol binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006810	transport
GO:0007165	signal transduction
GO:0008544	epidermis development
GO:0035115	embryonic forelimb morphogenesis
GO:0042573	retinoic acid metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

Method

Confidence

Comments

ENSMUSG00000004885

View Gene Order

Ortholuge

SSD Ortholog

Ortholog supports species divergence

ENSBTAG00000005716

Not yet available

Ortholuge

SSD Ortholog

Ortholog supports species divergence

Pathways

NETPATH

REACTOME

REACT_22258

Metabolism of lipids and lipoproteins pathway

REACT_1046

Pyruvate metabolism and Citric Acid (TCA) cycle pathway

REACT_2071

Pyruvate metabolism pathway

REACT_11082

Import of palmitoyl-CoA into the mitochondrial matrix pathway

REACT_22279

Fatty acid, triacylglycerol, and ketone body metabolism pathway

REACT_111083

The citric acid (TCA) cycle and respiratory electron transport pathway

REACT_111217

Metabolism pathway

REACT_12528

Regulation of pyruvate dehydrogenase (PDH) complex pathway

KEGG

INOH

PID BIOCARTA

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_001199723 NM_001878 XM_006711169

HUGO

OMIM

CCDS

CCDS1152

HPRD

08353

IMGT

EMBL

GenPept

RNA Seq Atlas