Homo sapiens Gene: CRABP2
Summary
InnateDB Gene IDBG-103584.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CRABP2
Gene Name cellular retinoic acid binding protein 2
Synonyms CRABP-II; RBP6;
Species Homo sapiens
Ensembl Gene ENSG00000143320
Encoded Proteins
cellular retinoic acid binding protein 2
cellular retinoic acid binding protein 2
cellular retinoic acid binding protein 2
cellular retinoic acid binding protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the retinoic acid (RA, a form of vitamin A) binding protein family and lipocalin/cytosolic fatty-acid binding protein family. The protein is a cytosol-to-nuclear shuttling protein, which facilitates RA binding to its cognate receptor complex and transfer to the nucleus. It is involved in the retinoid signaling pathway, and is associated with increased circulating low-density lipoprotein cholesterol. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:156699606-156705816
Strand Reverse strand
Band q23.1
Transcripts
ENST00000368222 ENSP00000357205
ENST00000368221 ENSP00000357204
ENST00000368220 ENSP00000357203
ENST00000621784 ENSP00000482841
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001972 retinoic acid binding
GO:0005215 transporter activity
GO:0005501 retinoid binding
GO:0016918 retinal binding
GO:0019841 retinol binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006810 transport
GO:0007165 signal transduction
GO:0008544 epidermis development
GO:0035115 embryonic forelimb morphogenesis
GO:0042573 retinoic acid metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Metabolism of lipids and lipoproteins pathway
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
Pyruvate metabolism pathway
Import of palmitoyl-CoA into the mitochondrial matrix pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
The citric acid (TCA) cycle and respiratory electron transport pathway
Metabolism pathway
Regulation of pyruvate dehydrogenase (PDH) complex pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001199723 NM_001878 XM_006711169
HUGO
OMIM
CCDS CCDS1152
HPRD 08353
IMGT
EMBL
GenPept
RNA Seq Atlas