Version 5.4
Homo sapiens Protein: CRABP2
Summary
InnateDB Protein IDBP-103586.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CRABP2
Protein Name cellular retinoic acid binding protein 2
Synonyms CRABP-II; RBP6;
Species Homo sapiens
Ensembl Protein ENSP00000357205
InnateDB Gene IDBG-103584 (CRABP2)
Protein Structure
UniProt Annotation
Function Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.
Subcellular Localization Cytoplasm. Endoplasmic reticulum. Nucleus. Note=Upon ligand binding, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005501 retinoid binding
GO:0016918 retinal binding
GO:0019841 retinol binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006810 transport
GO:0007165 signal transduction
GO:0008544 epidermis development
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000463 Cytosolic fatty-acid binding
IPR000566 Lipocalin/cytosolic fatty-acid binding domain
IPR011038 Calycin-like
PFAM PF00061
PF08212
PRINTS PR00178
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P29373
PhosphoSite PhosphoSite-P29373
TrEMBL Q5SYZ4
UniProt Splice Variant
Entrez Gene 1382
UniGene
RefSeq NP_001869
HUGO HGNC:2339
OMIM 180231
CCDS CCDS1152
HPRD 08353
IMGT
EMBL AB593017 AK312007 AL590666 BC001109 BT019827 CH471121 CR450357 M68867 M97814 M97815
GenPept AAA52068 AAA58430 AAH01109 AAV38630 BAG34945 BAJ83972 CAG29353 CAI16339 EAW52921 EAW52922

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca