Homo sapiens Gene: MRPL24
Summary
InnateDB Gene IDBG-103603.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MRPL24
Gene Name mitochondrial ribosomal protein L24
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000143314
Encoded Proteins
mitochondrial ribosomal protein L24
mitochondrial ribosomal protein L24
mitochondrial ribosomal protein L24
mitochondrial ribosomal protein L24
mitochondrial ribosomal protein L24
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which is more than twice the size of its E.coli counterpart (EcoL24). Sequence analysis identified two transcript variants that encode the same protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:156737303-156741590
Strand Reverse strand
Band q23.1
Transcripts
ENST00000361531 ENSP00000354525
ENST00000368211 ENSP00000357194
ENST00000434558 ENSP00000411369
ENST00000412846 ENSP00000406681
ENST00000420938 ENSP00000409803
ENST00000478899
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
Experimentally validated
Total 31 [view]
Protein-Protein 30 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005622 intracellular
GO:0005739 mitochondrion
GO:0005840 ribosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Organelle biogenesis and maintenance pathway
Mitochondrial translation pathway
Mitochondrial translation initiation pathway
Mitochondrial translation termination pathway
Mitochondrial translation elongation pathway
KEGG
Ribosome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_024540 NM_145729
HUGO
OMIM
CCDS CCDS1155
HPRD 14749
IMGT
EMBL
GenPept
RNA Seq Atlas