Version 5.4
Homo sapiens Gene: HDGF
Summary
InnateDB Gene IDBG-103610.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HDGF
Gene Name hepatoma-derived growth factor
Synonyms HMG1L2
Species Homo sapiens
Ensembl Gene ENSG00000143321
Encoded Proteins
IDBP-103612
hepatoma-derived growth factor
IDBP-103614
hepatoma-derived growth factor
IDBP-103616
hepatoma-derived growth factor
IDBP-595884
hepatoma-derived growth factor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the hepatoma-derived growth factor family. The encoded protein has mitogenic and DNA-binding activity and may play a role in cellular proliferation and differentiation. This gene was thought initially to be located on chromosome X, however, that location has been determined to correspond to a related pseudogene. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:156742107-156766925
Strand Reverse strand
Band q23.1
Transcripts
ENST00000357325 ENSP00000349878
ENST00000368209 ENSP00000357192
ENST00000368206 ENSP00000357189
ENST00000465180
ENST00000482651
ENST00000477306
ENST00000469145
ENST00000471377
ENST00000495212
ENST00000537739 ENSP00000443120
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 203 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 203 [view]
Protein-Protein 203 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0001106 RNA polymerase II transcription corepressor activity
GO:0001222 transcription corepressor binding
GO:0003677 DNA binding
GO:0008083 growth factor activity
GO:0008201 heparin binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006987 activation of signaling protein activity involved in unfolded protein response
GO:0007165 signal transduction
GO:0008283 cell proliferation
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0017053 transcriptional repressor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000004897
View Gene Order
ENSBTAG00000039793
Not yet available
Pathways
NETPATH
REACTOME
REACT_18273
XBP1(S) activates chaperone genes pathway
REACT_18368
IRE1alpha activates chaperones pathway
REACT_18356
Unfolded Protein Response (UPR) pathway
REACT_17015
Metabolism of proteins pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.506748
RefSeq NM_001126050 NM_001126051 NM_004494
HUGO
OMIM
CCDS CCDS1156 CCDS44247 CCDS44248
HPRD 02079
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca