Version 5.4
Homo sapiens Gene: PRCC
Summary
InnateDB Gene IDBG-103620.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRCC
Gene Name papillary renal cell carcinoma (translocation-associated)
Synonyms RCCP1; TPRC
Species Homo sapiens
Ensembl Gene ENSG00000143294
Encoded Proteins
IDBP-103624
papillary renal cell carcinoma (translocation-associated)
IDBP-389120
papillary renal cell carcinoma (translocation-associated)
IDBP-591387
papillary renal cell carcinoma (translocation-associated)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that may play a role in pre-mRNA splicing. Chromosomal translocations (X;1)(p11;q21) that result in fusion of this gene to TFE3 (GeneID 7030) have been associated with papillary renal cell carcinoma. A PRCC-TFE3 fusion protein is expressed in affected carcinomas and is likely associated with altered gene transactivation. This fusion protein has also been associated with disruption of the cell cycle.[provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:156750610-156800817
Strand Forward strand
Band q23.1
Transcripts
ENST00000271526 ENSP00000271526
ENST00000454659 ENSP00000403560
ENST00000491853
ENST00000473387
ENST00000459707
ENST00000469071
ENST00000526188 ENSP00000434762
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 18 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007093 mitotic cell cycle checkpoint
Cellular Component
GO:0005634 nucleus
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000004895
View Gene Order
ENSBTAG00000000608
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.516948 Hs.609662 Hs.678281
RefSeq NM_005973
HUGO
OMIM
CCDS CCDS1157
HPRD 01562
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca