Homo sapiens Gene: PRCC
Summary
InnateDB Gene IDBG-103620.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRCC
Gene Name papillary renal cell carcinoma (translocation-associated)
Synonyms RCCP1; TPRC;
Species Homo sapiens
Ensembl Gene ENSG00000143294
Encoded Proteins
papillary renal cell carcinoma (translocation-associated)
papillary renal cell carcinoma (translocation-associated)
papillary renal cell carcinoma (translocation-associated)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that may play a role in pre-mRNA splicing. Chromosomal translocations (X;1)(p11;q21) that result in fusion of this gene to TFE3 (GeneID 7030) have been associated with papillary renal cell carcinoma. A PRCC-TFE3 fusion protein is expressed in affected carcinomas and is likely associated with altered gene transactivation. This fusion protein has also been associated with disruption of the cell cycle.[provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:156750610-156800817
Strand Forward strand
Band q23.1
Transcripts
ENST00000271526 ENSP00000271526
ENST00000454659 ENSP00000403560
ENST00000491853
ENST00000473387
ENST00000459707
ENST00000469071
ENST00000526188 ENSP00000434762
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 18 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007093 mitotic cell cycle checkpoint
Cellular Component
GO:0005634 nucleus
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.516948 Hs.609662 Hs.678281
RefSeq NM_005973
HUGO
OMIM
CCDS CCDS1157
HPRD 01562
IMGT
EMBL
GenPept
RNA Seq Atlas