InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PRCC

Summary

InnateDB Protein

IDBP-103624.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRCC

Protein Name

papillary renal cell carcinoma (translocation-associated)

Synonyms

RCCP1; TPRC;

Species

Homo sapiens

Ensembl Protein

ENSP00000271526

InnateDB Gene

IDBG-103620 (PRCC)

Protein Structure

UniProt Annotation

Function

May regulate cell cycle progression through interaction with MAD2L2. {ECO:0000269PubMed:11717438}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:11717438}.

Disease Associations

Note=A chromosomal aberration involving PRCC is found in patients with papillary renal cell carcinoma. Translocation t(X;1)(p11.2;q21.2) with TFE3.

Tissue Specificity

Ubiquitous in fetal and adult tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	18 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007093

mitotic cell cycle checkpoint

Cellular Component

GO:0005634	nucleus
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

InterPro

IPR018800 Proline-rich protein PRCC

PFAM

PF10253

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q92733

PhosphoSite

PhosphoSite-Q92733

TrEMBL

UniProt Splice Variant

Entrez Gene

5546

UniGene

Hs.678281

RefSeq

NP_005964

HUGO

HGNC:9343

OMIM

179755

CCDS

CCDS1157

HPRD

01562

IMGT

EMBL

AK289872 AL590666 BC004913 CH471121 X97124 X99720

GenPept

AAH04913 BAF82561 CAA65791 CAA68060 CAI16350 EAW52909