InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ARHGEF11

Summary

InnateDB Gene

IDBG-103650.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARHGEF11

Gene Name

Rho guanine nucleotide exchange factor (GEF) 11

Synonyms

GTRAP48; PDZ-RHOGEF

Species

Homo sapiens

Ensembl Gene

ENSG00000132694

Encoded Proteins

IDBP-103652

Rho guanine nucleotide exchange factor (GEF) 11

IDBP-103654

Rho guanine nucleotide exchange factor (GEF) 11

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:156934840-157045370

Strand

Reverse strand

Band

q23.1

Transcripts

ENST00000368194	ENSP00000357177
ENST00000361409	ENSP00000354644
ENST00000487682
ENST00000492592
ENST00000461678
ENST00000486670
ENST00000483682

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.

Experimentally validated
Total	23 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001664	G-protein coupled receptor binding
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005096	GTPase activator activity
GO:0005515	protein binding

Biological Process

GO:0000910	cytokinesis
GO:0001558	regulation of cell growth
GO:0006928	cellular component movement
GO:0006941	striated muscle contraction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007264	small GTPase mediated signal transduction
GO:0007266	Rho protein signal transduction
GO:0007411	axon guidance
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0030010	establishment of cell polarity
GO:0030036	actin cytoskeleton organization
GO:0032321	positive regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0043065	positive regulation of apoptotic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0097190	apoptotic signaling pathway