Homo sapiens Gene: ARHGEF11
Summary
InnateDB Gene IDBG-103650.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARHGEF11
Gene Name Rho guanine nucleotide exchange factor (GEF) 11
Synonyms GTRAP48; PDZ-RHOGEF;
Species Homo sapiens
Ensembl Gene ENSG00000132694
Encoded Proteins
Rho guanine nucleotide exchange factor (GEF) 11
Rho guanine nucleotide exchange factor (GEF) 11
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:156934840-157045370
Strand Reverse strand
Band q23.1
Transcripts
ENST00000368194 ENSP00000357177
ENST00000361409 ENSP00000354644
ENST00000487682
ENST00000492592
ENST00000461678
ENST00000486670
ENST00000483682
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
Experimentally validated
Total 23 [view]
Protein-Protein 23 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001664 G-protein coupled receptor binding
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005096 GTPase activator activity
GO:0005515 protein binding
Biological Process
GO:0000910 cytokinesis
GO:0001558 regulation of cell growth
GO:0006928 cellular component movement
GO:0006941 striated muscle contraction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0007266 Rho protein signal transduction
GO:0007411 axon guidance
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0030010 establishment of cell polarity
GO:0030036 actin cytoskeleton organization
GO:0032321 positive regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0038032 termination of G-protein coupled receptor signaling pathway
GO:0043065 positive regulation of apoptotic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Sema4D in semaphorin signaling pathway
G alpha (12/13) signalling events pathway
Developmental Biology pathway
Signalling by NGF pathway
Semaphorin interactions pathway
Signaling by Rho GTPases pathway
Signaling by GPCR pathway
Axon guidance pathway
p75 NTR receptor-mediated signalling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
NRAGE signals death through JNK pathway
Rho GTPase cycle pathway
Cell death signalling via NRAGE, NRIF and NADE pathway
Sema4D induced cell migration and growth-cone collapse pathway
KEGG
Vascular smooth muscle contraction pathway
INOH
PID BIOCARTA
PID NCI
Signaling events mediated by focal adhesion kinase
Regulation of RhoA activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.516954
RefSeq NM_014784 NM_198236 XM_005245629 XM_005245633 XM_006711663
HUGO
OMIM
CCDS CCDS1162 CCDS1163
HPRD 09302
IMGT
EMBL
GenPept
RNA Seq Atlas