InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ARHGEF11

Summary

InnateDB Gene

IDBG-631202.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARHGEF11

Gene Name

Uncharacterized protein

Synonyms

ARHGEF11

Species

Bos taurus

Ensembl Gene

ENSBTAG00000012361

Encoded Proteins

IDBP-682839

Rho guanine nucleotide exchange factor (GEF) 11

IDBP-682844

Rho guanine nucleotide exchange factor (GEF) 11

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000132694:
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:13887504-13970875

Strand

Forward strand

Band

Transcripts

ENSBTAT00000016407	ENSBTAP00000016407
ENSBTAT00000064318	ENSBTAP00000055453

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001664	G-protein coupled receptor binding
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding

Biological Process

GO:0007266	Rho protein signal transduction
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0032321	positive regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0035556	intracellular signal transduction
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0043547	positive regulation of GTPase activity
GO:0045893	positive regulation of transcription, DNA-templated