InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FCER1A

Summary

InnateDB Gene

IDBG-103887.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FCER1A

Gene Name

Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide

Synonyms

FCE1A; FcERI

Species

Homo sapiens

Ensembl Gene

ENSG00000179639

Encoded Proteins

IDBP-103889

Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide

IDBP-103893

Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine that are responsible for allergy symptoms are released. This receptor is comprised of an alpha subunit, a beta subunit, and two gamma subunits. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:159289714-159308224

Strand

Forward strand

Band

q23.2

Transcripts

ENST00000368115	ENSP00000357097
ENST00000368114	ENSP00000357096

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.

Experimentally validated
Total	22 [view]
Protein-Protein	14 [view]
Protein-DNA	8 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019767	IgE receptor activity
GO:0019863	IgE binding

Biological Process

GO:0000187	activation of MAPK activity
GO:0001812	positive regulation of type I hypersensitivity
GO:0001820	serotonin secretion
GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0007257	activation of JUN kinase activity
GO:0019370	leukotriene biosynthetic process
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0043306	positive regulation of mast cell degranulation
GO:0045087	innate immune response
GO:0045401	positive regulation of interleukin-3 biosynthetic process
GO:0045425	positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050850	positive regulation of calcium-mediated signaling

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0009986	cell surface

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000005339

View Gene Order

ENSBTAG00000012887

Not yet available

Pathways

NETPATH

REACTOME

REACT_163994

FCERI mediated NF-kB activation pathway

REACT_163769

Role of LAT2/NTAL/LAB on calcium mobilization pathway

REACT_6802

Innate Immune System pathway

REACT_163936

Fc epsilon receptor (FCERI) signaling pathway

REACT_6900

Immune System pathway

REACT_163834

FCERI mediated Ca+2 mobilization pathway

REACT_163701

FCERI mediated MAPK activation pathway

KEGG

hsa04664

Fc epsilon RI signaling pathway pathway

hsa05310

Asthma pathway

INOH

PID NCI

fcer1pathway

Fc-epsilon receptor I signaling in mast cells

Cross-References

SwissProt

P12319

TrEMBL

Q8WYP6

UniProt Splice Variant

Entrez Gene

2205

UniGene

Hs.897

RefSeq

NM_002001

HUGO

HGNC:3609

OMIM

147140

CCDS

CCDS1184

HPRD

00917

IMGT

EMBL

AB059236 BC005912 J03605 X06948

GenPept

AAA36204 AAH05912 BAB84120 CAA30025

RNA Seq Atlas

2205