Homo sapiens Gene: FCER1A
Summary
InnateDB Gene IDBG-103887.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FCER1A
Gene Name Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
Synonyms FCE1A; FcERI;
Species Homo sapiens
Ensembl Gene ENSG00000179639
Encoded Proteins
Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine that are responsible for allergy symptoms are released. This receptor is comprised of an alpha subunit, a beta subunit, and two gamma subunits. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:159289714-159308224
Strand Forward strand
Band q23.2
Transcripts
ENST00000368115 ENSP00000357097
ENST00000368114 ENSP00000357096
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
Experimentally validated
Total 22 [view]
Protein-Protein 14 [view]
Protein-DNA 8 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019767 IgE receptor activity
GO:0019863 IgE binding
Biological Process
GO:0000187 activation of MAPK activity
GO:0001812 positive regulation of type I hypersensitivity
GO:0001820 serotonin secretion
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007257 activation of JUN kinase activity
GO:0019370 leukotriene biosynthetic process
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0043306 positive regulation of mast cell degranulation
GO:0045087 innate immune response
GO:0045401 positive regulation of interleukin-3 biosynthetic process
GO:0045425 positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050850 positive regulation of calcium-mediated signaling
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
FCERI mediated NF-kB activation pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Innate Immune System pathway
Fc epsilon receptor (FCERI) signaling pathway
Immune System pathway
FCERI mediated Ca+2 mobilization pathway
FCERI mediated MAPK activation pathway
KEGG
Fc epsilon RI signaling pathway pathway
Asthma pathway
INOH
PID BIOCARTA
Fc epsilon receptor i signaling in mast cells [Biocarta view]
PID NCI
Fc-epsilon receptor I signaling in mast cells
Cross-References
SwissProt P12319
TrEMBL E9PRN1 Q8WYP6
UniProt Splice Variant
Entrez Gene 2205
UniGene Hs.897
RefSeq NM_002001
HUGO HGNC:3609
OMIM 147140
CCDS CCDS1184
HPRD
IMGT
EMBL AB059236 AL513323 BC005912 J03605 X06948
GenPept AAA36204 AAH05912 BAB84120 CAA30025
RNA Seq Atlas 2205