InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: KCNJ10

Summary

InnateDB Gene

IDBG-103978.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KCNJ10

Gene Name

potassium inwardly-rectifying channel, subfamily J, member 10

Synonyms

BIRK-10; KCNJ13-PEN; KIR1.2; KIR4.1; SESAME

Species

Homo sapiens

Ensembl Gene

ENSG00000177807

Encoded Proteins

IDBP-103980

potassium inwardly-rectifying channel, subfamily J, member 10

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the inward rectifier-type potassium channel family, characterized by having a greater tendency to allow potassium to flow into, rather than out of, a cell. The encoded protein may form a heterodimer with another potassium channel protein and may be responsible for the potassium buffering action of glial cells in the brain. Mutations in this gene have been associated with seizure susceptibility of common idiopathic generalized epilepsy syndromes. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:160037467-160070248

Strand

Reverse strand

Band

q23.2

Transcripts

ENST00000368089

ENSP00000357068

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005242	inward rectifier potassium channel activity
GO:0005267	potassium channel activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0015272	ATP-activated inward rectifier potassium channel activity
GO:0042802	identical protein binding

Biological Process

GO:0006813	potassium ion transport
GO:0006954	inflammatory response
GO:0007268	synaptic transmission
GO:0007601	visual perception
GO:0007628	adult walking behavior
GO:0009637	response to blue light
GO:0010107	potassium ion import
GO:0014003	oligodendrocyte development
GO:0021554	optic nerve development
GO:0022010	central nervous system myelination
GO:0034765	regulation of ion transmembrane transport
GO:0042391	regulation of membrane potential
GO:0048169	regulation of long-term neuronal synaptic plasticity
GO:0051289	protein homotetramerization
GO:0051384	response to glucocorticoid
GO:0051385	response to mineralocorticoid
GO:0051930	regulation of sensory perception of pain
GO:0051935	L-glutamate uptake involved in synaptic transmission
GO:0051938	L-glutamate import
GO:0055075	potassium ion homeostasis
GO:0060075	regulation of resting membrane potential
GO:0060081	membrane hyperpolarization
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005902	microvillus
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane
GO:0097449	astrocyte projection