InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KCNJ10

Summary

InnateDB Protein

IDBP-103980.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KCNJ10

Protein Name

potassium inwardly-rectifying channel, subfamily J, member 10

Synonyms

BIRK-10; KCNJ13-PEN; KIR1.2; KIR4.1; SESAME;

Species

Homo sapiens

Ensembl Protein

ENSP00000357068

InnateDB Gene

IDBG-103978 (KCNJ10)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005242	inward rectifier potassium channel activity
GO:0005267	potassium channel activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0015272	ATP-activated inward rectifier potassium channel activity
GO:0042802	identical protein binding

Biological Process

GO:0006813	potassium ion transport
GO:0006954	inflammatory response
GO:0007268	synaptic transmission
GO:0007601	visual perception
GO:0007628	adult walking behavior
GO:0009637	response to blue light
GO:0010107	potassium ion import
GO:0014003	oligodendrocyte development
GO:0021554	optic nerve development
GO:0022010	central nervous system myelination
GO:0034765	regulation of ion transmembrane transport
GO:0042391	regulation of membrane potential
GO:0048169	regulation of long-term neuronal synaptic plasticity
GO:0051289	protein homotetramerization
GO:0051384	response to glucocorticoid
GO:0051385	response to mineralocorticoid
GO:0051930	regulation of sensory perception of pain
GO:0051935	L-glutamate uptake involved in synaptic transmission
GO:0051938	L-glutamate import
GO:0055075	potassium ion homeostasis
GO:0060075	regulation of resting membrane potential
GO:0060081	membrane hyperpolarization
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005902	microvillus
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane
GO:0097449	astrocyte projection

Protein Structure and Domains

PDB ID

InterPro

IPR003268 Potassium channel, inwardly rectifying, Kir1.1
IPR003269 Potassium channel, inwardly rectifying, Kir1.2
IPR014756 Immunoglobulin E-set
IPR016449 Potassium channel, inwardly rectifying, Kir

PFAM

PF01007

PRINTS

PR01321
PR01322
PR01320

PIRSF

PIRSF005465

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt