Homo sapiens Gene: BMP1
Summary
InnateDB Gene IDBG-10398.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BMP1
Gene Name bone morphogenetic protein 1
Synonyms OI13; PCOLC; PCP; PCP2; TLD;
Species Homo sapiens
Ensembl Gene ENSG00000168487
Encoded Proteins
bone morphogenetic protein 1
bone morphogenetic protein 1
bone morphogenetic protein 1
bone morphogenetic protein 1
bone morphogenetic protein 1
bone morphogenetic protein 1
bone morphogenetic protein 1
bone morphogenetic protein 1
bone morphogenetic protein 1
bone morphogenetic protein 1
bone morphogenetic protein 1
bone morphogenetic protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that is capable of inducing formation of cartilage in vivo. Although other bone morphogenetic proteins are members of the TGF-beta superfamily, this gene encodes a protein that is not closely related to other known growth factors. This gene is expressed as alternatively spliced variants that share an N-terminal protease domain but differ in their C-terminal region. [provided by RefSeq, Aug 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:22164736-22212326
Strand Forward strand
Band p21.3
Transcripts
ENST00000354870 ENSP00000346941
ENST00000306349 ENSP00000306121
ENST00000306385 ENSP00000305714
ENST00000397814 ENSP00000380915
ENST00000520970 ENSP00000428332
ENST00000518913 ENSP00000427950
ENST00000520982 ENSP00000428798
ENST00000520626 ENSP00000430015
ENST00000518656 ENSP00000430977
ENST00000483364 ENSP00000428249
ENST00000471755 ENSP00000428665
ENST00000521385 ENSP00000430406
ENST00000521521
ENST00000523849
ENST00000523457
ENST00000523749
ENST00000517324
ENST00000522332
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0005125 cytokine activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0001501 skeletal system development
GO:0001502 cartilage condensation
GO:0001503 ossification
GO:0006508 proteolysis
GO:0007275 multicellular organismal development
GO:0022617 extracellular matrix disassembly
GO:0030154 cell differentiation
GO:0030198 extracellular matrix organization
GO:0042157 lipoprotein metabolic process
GO:0044281 small molecule metabolic process
GO:0061036 positive regulation of cartilage development
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0005794 Golgi apparatus
GO:0031988 membrane-bounded vesicle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Collagen biosynthesis and modifying enzymes pathway
Extracellular matrix organization pathway
Degradation of the extracellular matrix pathway
Crosslinking of collagen fibrils pathway
Assembly of collagen fibrils and other multimeric structures pathway
Collagen formation pathway
Anchoring fibril formation pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL B7ZKR5
UniProt Splice Variant
Entrez Gene 649
UniGene Hs.1274
RefSeq NM_001199 NM_006129
HUGO HGNC:1067
OMIM 112264
CCDS CCDS34856 CCDS6026
HPRD 00209
IMGT
EMBL AC105206 BC143338
GenPept AAI43339
RNA Seq Atlas 649