Mus musculus Gene: Bmp1
Summary
InnateDB Gene IDBG-178672.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Bmp1
Gene Name bone morphogenetic protein 1
Synonyms Pcp; Tld;
Species Mus musculus
Ensembl Gene ENSMUSG00000022098
Encoded Proteins
bone morphogenetic protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a metalloproteinase that is essential for forming the extracellular matrix and is able to induce ectopic bone formation. The encoded protein is not closely related to transforming growth factor-beta, unlike other bone morphogenetic proteins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2010]
This gene encodes a metalloproteinase that plays an essential role in the formation of the extracellular matrix and is also able to induce ectopic bone formation. Unlike other bone morphogenetic proteins, the protein encoded by this gene is not closely related to transforming growth factor-beta. This protein plays in role several developmental processes. In humans, mutations in this gene are associated with osteogenesis imperfecta and with increased bone mineral density and multiple recurrent fractures. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:70474557-70520260
Strand Reverse strand
Band D2
Transcripts
ENSMUST00000022693 ENSMUSP00000022693
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0005125 cytokine activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0001503 ossification
GO:0006508 proteolysis
GO:0030154 cell differentiation
GO:0051216 cartilage development
GO:0061036 positive regulation of cartilage development
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0005794 Golgi apparatus
GO:0031988 membrane-bounded vesicle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Collagen formation pathway
Assembly of collagen fibrils and other multimeric structures pathway
Collagen biosynthesis and modifying enzymes pathway
HDL-mediated lipid transport pathway
Metabolism pathway
Anchoring fibril formation pathway
Extracellular matrix organization pathway
Metabolism of lipids and lipoproteins pathway
Lipid digestion, mobilization, and transport pathway
Lipoprotein metabolism pathway
Crosslinking of collagen fibrils pathway
Degradation of the extracellular matrix pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Collagen biosynthesis and modifying enzymes pathway
Extracellular matrix organization pathway
Degradation of the extracellular matrix pathway
Crosslinking of collagen fibrils pathway
Assembly of collagen fibrils and other multimeric structures pathway
Collagen formation pathway
Anchoring fibril formation pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P98063
TrEMBL Q6P550
UniProt Splice Variant
Entrez Gene 12153
UniGene Mm.395268
RefSeq NM_009755 XM_006518459 XM_006518460 XM_006518461 XM_006518462 XM_006518466
OMIM
CCDS CCDS36972
HPRD
IMGT
MGI ID MGI:88176
MGI Symbol Bmp1
EMBL AC122268 BC063079 BC066062 L24755
GenPept AAA37306 AAH63079 AAH66062
RNA Seq Atlas 12153