InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Bmp1

Summary

InnateDB Gene

IDBG-178672.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bmp1

Gene Name

bone morphogenetic protein 1

Synonyms

Pcp; Tld

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022098

Encoded Proteins

IDBP-178676

bone morphogenetic protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a metalloproteinase that is essential for forming the extracellular matrix and is able to induce ectopic bone formation. The encoded protein is not closely related to transforming growth factor-beta, unlike other bone morphogenetic proteins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2010]
This gene encodes a metalloproteinase that plays an essential role in the formation of the extracellular matrix and is also able to induce ectopic bone formation. Unlike other bone morphogenetic proteins, the protein encoded by this gene is not closely related to transforming growth factor-beta. This protein plays in role several developmental processes. In humans, mutations in this gene are associated with osteogenesis imperfecta and with increased bone mineral density and multiple recurrent fractures. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:70474557-70520260

Strand

Reverse strand

Band

Transcripts

ENSMUST00000022693

ENSMUSP00000022693

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0005125	cytokine activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0008233	peptidase activity
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0001503	ossification
GO:0006508	proteolysis
GO:0030154	cell differentiation
GO:0051216	cartilage development
GO:0061036	positive regulation of cartilage development