Version 5.4
Homo sapiens Gene: DCAF8
Summary
InnateDB Gene IDBG-104017.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DCAF8
Gene Name DDB1 and CUL4 associated factor 8
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000132716
Encoded Proteins
IDBP-104019
DDB1 and CUL4 associated factor 8
IDBP-104021
DDB1 and CUL4 associated factor 8
IDBP-104023
DDB1 and CUL4 associated factor 8
IDBP-293108
DDB1 and CUL4 associated factor 8
IDBP-389246
DDB1 and CUL4 associated factor 8
IDBP-389247
DDB1 and CUL4 associated factor 8
IDBP-389248
DDB1 and CUL4 associated factor 8
IDBP-810622
DDB1 and CUL4 associated factor 8
IDBP-810623
DDB1 and CUL4 associated factor 8
IDBP-810626
DDB1 and CUL4 associated factor 8
IDBP-810627
DDB1 and CUL4 associated factor 8
IDBP-810630
DDB1 and CUL4 associated factor 8
IDBP-810633
DDB1 and CUL4 associated factor 8
IDBP-810629
DDB1 and CUL4 associated factor 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a WD repeat-containing protein that interacts with the Cul4-Ddb1 E3 ligase macromolecular complex. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:160215715-160262531
Strand Reverse strand
Band q23.2
Transcripts
ENST00000368074 ENSP00000357053
ENST00000326837 ENSP00000318227
ENST00000368073 ENSP00000357052
ENST00000407642 ENSP00000384118
ENST00000447377 ENSP00000413688
ENST00000440682 ENSP00000411875
ENST00000419626 ENSP00000409434
ENST00000477163 ENSP00000477386
ENST00000473382 ENSP00000476539
ENST00000476033
ENST00000461888 ENSP00000476407
ENST00000490368 ENSP00000477255
ENST00000497354
ENST00000481831
ENST00000466253
ENST00000475733 ENSP00000476351
ENST00000495887 ENSP00000477012
ENST00000610139 ENSP00000477464
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
Experimentally validated
Total 40 [view]
Protein-Protein 39 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0016567 protein ubiquitination
Cellular Component
GO:0080008 Cul4-RING E3 ubiquitin ligase complex
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.632447 Hs.635593
RefSeq NM_015726
HUGO
OMIM
CCDS CCDS1200
HPRD 18300
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca