Version 5.4
Homo sapiens Protein: DCAF8
Summary
InnateDB Protein IDBP-104023.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DCAF8
Protein Name DDB1 and CUL4 associated factor 8
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000357052
InnateDB Gene IDBG-104017 (DCAF8)
Protein Structure
UniProt Annotation
Function May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000269PubMed:16949367, ECO:0000269PubMed:16964240}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
Experimentally validated
Total 40 [view]
Protein-Protein 39 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0016567 protein ubiquitination
Cellular Component
GO:0080008 Cul4-RING E3 ubiquitin ligase complex
Protein Structure and Domains
PDB ID
InterPro IPR001680 WD40 repeat
IPR017986 WD40-repeat-containing domain
PFAM PF00400
PRINTS
PIRSF
SMART SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5TAQ9
PhosphoSite PhosphoSite-Q5TAQ9
TrEMBL V9GYQ9
UniProt Splice Variant
Entrez Gene 50717
UniGene Hs.635593
RefSeq
HUGO HGNC:24891
OMIM 615820
CCDS CCDS1200
HPRD 18300
IMGT
EMBL AK223475 AK303188 AL139011 AL513282 BC013107 BC080597 BC098271 BC099709 BC099846 BC111063 CH471121 CR749801 U06631
GenPept AAA16607 AAH13107 AAH80597 AAH98271 AAH99709 AAH99846 AAI11064 BAD97195 BAH13915 CAH18661 CAI15993 EAW52731 EAW52732

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca