InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FCER1G

Summary

InnateDB Gene

IDBG-104229.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FCER1G

Gene Name

Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide

Synonyms

FCRG

Species

Homo sapiens

Ensembl Gene

ENSG00000158869

Encoded Proteins

IDBP-104231

Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide

IDBP-104233

Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The high affinity IgE receptor is a key molecule involved in allergic reactions. It is a tetramer composed of 1 alpha, 1 beta, and 2 gamma chains. The gamma chains are also subunits of other Fc receptors. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:161215234-161220699

Strand

Forward strand

Band

q23.3

Transcripts

ENST00000367992	ENSP00000356971
ENST00000289902	ENSP00000289902
ENST00000490414

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.

Experimentally validated
Total	21 [view]
Protein-Protein	17 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0005515	protein binding
GO:0019767	IgE receptor activity
GO:0019863	IgE binding
GO:0019864	IgG binding

Biological Process

GO:0001798	positive regulation of type IIa hypersensitivity
GO:0001805	positive regulation of type III hypersensitivity
GO:0001812	positive regulation of type I hypersensitivity
GO:0002283	neutrophil activation involved in immune response
GO:0002431	Fc receptor mediated stimulatory signaling pathway
GO:0002554	serotonin secretion by platelet
GO:0006911	phagocytosis, engulfment
GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0007229	integrin-mediated signaling pathway
GO:0007596	blood coagulation
GO:0010543	regulation of platelet activation
GO:0016064	immunoglobulin mediated immune response
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0030168	platelet activation
GO:0030593	neutrophil chemotaxis
GO:0032733	positive regulation of interleukin-10 production
GO:0032755	positive regulation of interleukin-6 production
GO:0032760	positive regulation of tumor necrosis factor production
GO:0032765	positive regulation of mast cell cytokine production
GO:0033026	negative regulation of mast cell apoptotic process
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042742	defense response to bacterium
GO:0043306	positive regulation of mast cell degranulation
GO:0045087	innate immune response
GO:0045576	mast cell activation
GO:0050766	positive regulation of phagocytosis
GO:0050776	regulation of immune response
GO:0050778	positive regulation of immune response
GO:0050900	leukocyte migration
GO:0072659	protein localization to plasma membrane

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0032998	Fc-epsilon receptor I complex