InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FCER1G

Summary

InnateDB Protein

IDBP-104233.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FCER1G

Protein Name

Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide

Synonyms

FCRG;

Species

Homo sapiens

Ensembl Protein

ENSP00000289902

InnateDB Gene

IDBG-104229 (FCER1G)

Protein Structure

UniProt Annotation

Function

Associates with a variety of FcR alpha chains to form a functional signaling complex. Regulates several aspects of the immune response. The gamma subunit has a critical role in allowing the IgE Fc receptor to reach the cell surface. Also involved in collagen-mediated platelet activation and in neutrophil activation mediated by integrin. {ECO:0000269PubMed:8611682}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:8611682}; Single-pass type I membrane protein {ECO:0000269PubMed:8611682}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.

Experimentally validated
Total	21 [view]
Protein-Protein	17 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0005515	protein binding
GO:0019767	IgE receptor activity
GO:0019863	IgE binding
GO:0019864	IgG binding

Biological Process

GO:0001798	positive regulation of type IIa hypersensitivity
GO:0001805	positive regulation of type III hypersensitivity
GO:0001812	positive regulation of type I hypersensitivity
GO:0002283	neutrophil activation involved in immune response
GO:0002431	Fc receptor mediated stimulatory signaling pathway
GO:0002554	serotonin secretion by platelet
GO:0006911	phagocytosis, engulfment
GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0007229	integrin-mediated signaling pathway
GO:0007596	blood coagulation
GO:0010543	regulation of platelet activation
GO:0016064	immunoglobulin mediated immune response
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0030168	platelet activation
GO:0030593	neutrophil chemotaxis
GO:0032733	positive regulation of interleukin-10 production
GO:0032755	positive regulation of interleukin-6 production
GO:0032760	positive regulation of tumor necrosis factor production
GO:0032765	positive regulation of mast cell cytokine production
GO:0033026	negative regulation of mast cell apoptotic process
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042742	defense response to bacterium
GO:0043306	positive regulation of mast cell degranulation
GO:0045087	innate immune response
GO:0045576	mast cell activation
GO:0050766	positive regulation of phagocytosis
GO:0050776	regulation of immune response
GO:0050778	positive regulation of immune response
GO:0050900	leukocyte migration
GO:0072659	protein localization to plasma membrane

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0032998	Fc-epsilon receptor I complex

Protein Structure and Domains

PDB ID

InterPro

IPR003110 Phosphorylated immunoreceptor signalling ITAM
IPR021663 T-cell surface glycoprotein CD3 zeta/eta subunit/High affinity IgE receptor gamma subunit

PFAM

PF02189
PF11628

PRINTS

PIRSF

SMART

SM00077

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P30273