Homo sapiens Gene: MCAT
Summary
InnateDB Gene IDBG-10428.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MCAT
Gene Name malonyl CoA:ACP acyltransferase (mitochondrial)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000100294
Encoded Proteins
malonyl CoA:ACP acyltransferase (mitochondrial)
malonyl CoA:ACP acyltransferase (mitochondrial)
malonyl CoA:ACP acyltransferase (mitochondrial)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is found exclusively in the mitochondrion, where it catalyzes the transfer of a malonyl group from malonyl-CoA to the mitochondrial acyl carrier protein. The encoded protein may be part of a fatty acid synthase complex that is more like the type II prokaryotic and plastid complexes rather than the type I human cytosolic complex. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:43132206-43143394
Strand Reverse strand
Band q13.2
Transcripts
ENST00000290429 ENSP00000290429
ENST00000327555 ENSP00000331306
ENST00000464244
ENST00000608052 ENSP00000477216
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004314 [acyl-carrier-protein] S-malonyltransferase activity
GO:0016740 transferase activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006633 fatty acid biosynthetic process
GO:0008152 metabolic process
Cellular Component
GO:0005739 mitochondrion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Fatty acid biosynthesis pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q8IVS2
TrEMBL V9GYY6
UniProt Splice Variant
Entrez Gene 27349
UniGene Hs.349111
RefSeq NM_014507 NM_173467
HUGO HGNC:29622
OMIM 614479
CCDS CCDS14045 CCDS33660
HPRD
IMGT
EMBL AK314059 AL022237 AL359401 AL359403 BC030985 BC042195 CH471138
GenPept AAH30985 AAH42195 BAG36765 CAA18261 CAB94789 CAB94790 CAQ07851 EAW73286
RNA Seq Atlas 27349