Homo sapiens Gene: FCGR3B
Summary
InnateDB Gene IDBG-104303.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FCGR3B
Gene Name Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
Synonyms CD16; CD16b; FCG3; FCGR3; FCR-10; FCRIII; FCRIIIb;
Species Homo sapiens
Ensembl Gene ENSG00000162747
Encoded Proteins
Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a low affinity receptor for the Fc region of gamma immunoglobulins (IgG). The encoded protein acts as a monomer and can bind either monomeric or aggregated IgG. This gene may function to capture immune complexes in the peripheral circulation. Several transcript variants encoding different isoforms have been found for this gene. A highly-similar gene encoding a related protein is also found on chromosome 1. [provided by RefSeq, Aug 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:161623196-161631963
Strand Reverse strand
Band q23.3
Transcripts
ENST00000367964 ENSP00000356941
ENST00000294800 ENSP00000294800
ENST00000421702 ENSP00000394204
ENST00000531221 ENSP00000433642
ENST00000533780
ENST00000534776 ENSP00000437084
ENST00000534489
ENST00000614870 ENSP00000478466
ENST00000613418 ENSP00000482838
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019864 IgG binding
Biological Process
GO:0006955 immune response
Cellular Component
GO:0005886 plasma membrane
GO:0031225 anchored component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Pathways
NETPATH
RANKL pathway
REACTOME
KEGG
Phagosome pathway
Osteoclast differentiation pathway
Natural killer cell mediated cytotoxicity pathway
Leishmaniasis pathway
Staphylococcus aureus infection pathway
Systemic lupus erythematosus pathway
INOH
PID BIOCARTA
Ras-independent pathway in nk cell-mediated cytotoxicity [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.694258 Hs.736230
RefSeq NM_000570 NM_001244753 NM_001271035 NM_001271036 NM_001271037
HUGO
OMIM
CCDS CCDS41433 CCDS58040 CCDS72960 CCDS72961
HPRD 09951
IMGT
EMBL
GenPept
RNA Seq Atlas