InnateDB Protein
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IDBP-104305.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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FCGR3B
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Protein Name
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Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
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Synonyms
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CD16; CD16b; FCG3; FCGR3; FCR-10; FCRIII; FCRIIIb;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000356941
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InnateDB Gene
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IDBG-104303 (FCGR3B)
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Protein Structure
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Function |
Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.
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Subcellular Localization |
Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Secreted after cleavage.
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Disease Associations |
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Tissue Specificity |
Expressed specifically by polymorphonuclear leukocytes (neutrophils). Also expressed by stimulated eosinophils.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR003599
Immunoglobulin subtype
IPR007110
Immunoglobulin-like domain
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
SM00409
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TIGRFAMs |
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Modification |
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SwissProt |
O75015
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PhosphoSite |
PhosphoSite-O75015
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TrEMBL |
E9PNY5
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UniProt Splice Variant |
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Entrez Gene |
2215
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UniGene |
Hs.736230
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RefSeq |
NP_000561
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HUGO |
HGNC:3620
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OMIM |
610665
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CCDS |
CCDS41433
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HPRD |
09951
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IMGT |
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EMBL |
AJ581669
AL451067
J04162
M24854
X07934
X16863
Z46223
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GenPept |
AAA35881
AAA53507
CAA30758
CAA34753
CAA86296
CAE46408
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