Homo sapiens Gene: UHMK1
Summary
InnateDB Gene IDBG-104384.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UHMK1
Gene Name U2AF homology motif (UHM) kinase 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000152332
Encoded Proteins
U2AF homology motif (UHM) kinase 1
U2AF homology motif (UHM) kinase 1
U2AF homology motif (UHM) kinase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The gene encodes a serine/threonine protein kinase that promotes cell cycle progression through G1 by phosphorylation of the cyclin-dependent kinase inhibitor 1B (p27Kip1), which causes nuclear export and degradation. The encoded protein is also thought to function in the adult nervous system and the gene has been associated with schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:162497251-162529629
Strand Forward strand
Band q23.3
Transcripts
ENST00000282169
ENST00000489294 ENSP00000420270
ENST00000545294 ENSP00000441226
ENST00000538489 ENSP00000446416
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 8 [view]
Protein-DNA 3 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016740 transferase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019899 enzyme binding
GO:0043021 ribonucleoprotein complex binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007050 cell cycle arrest
GO:0018105 peptidyl-serine phosphorylation
GO:0031175 neuron projection development
GO:0045948 positive regulation of translational initiation
GO:0046777 protein autophosphorylation
GO:0046825 regulation of protein export from nucleus
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0030424 axon
GO:0032839 dendrite cytoplasm
GO:0071598 neuronal ribonucleoprotein granule
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt Q8TAS1
TrEMBL
UniProt Splice Variant
Entrez Gene 127933
UniGene Hs.127310 Hs.601000 Hs.708149 Hs.713167
RefSeq NM_175866 NM_144624 NM_001184763
HUGO HGNC:19683
OMIM 608849
CCDS CCDS1239 CCDS53424 CCDS53423
HPRD 12318
IMGT
EMBL AJ536197 AK058195 AK292369 AL359699 BC014917 BC026046 CH471067
GenPept AAH14917 AAH26046 BAF85058 CAD60192 CAH70392 EAW90706 EAW90707
RNA Seq Atlas 127933