Version 5.4
Homo sapiens Gene: LMX1A
Summary
InnateDB Gene IDBG-104454.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LMX1A
Gene Name LIM homeobox transcription factor 1, alpha
Synonyms LMX1; LMX1.1
Species Homo sapiens
Ensembl Gene ENSG00000162761
Encoded Proteins
IDBP-104456
LIM homeobox transcription factor 1, alpha
IDBP-104458
LIM homeobox transcription factor 1, alpha
IDBP-104460
LIM homeobox transcription factor 1, alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a homeodomain and LIM-domain containing protein. The encoded protein is a transcription factor that acts as a positive regulator of insulin gene transcription. This gene also plays a role in the development of dopamine producing neurons during embryogenesis. Mutations in this gene are associated with an increased risk of developing Parkinson's disease. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
This gene encodes a homeodomain and LIM-domain containing protein. The encoded protein is a transcription factor that acts as a positive regulator of insulin gene transcription. This gene also plays a role in the development of dopamine producing neurons during embryogenesis. Mutations in this gene are associated with an increased risk of developing Parkinson\'s disease. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:165201867-165356715
Strand Reverse strand
Band q23.3
Transcripts
ENST00000342310 ENSP00000340226
ENST00000294816 ENSP00000294816
ENST00000367893 ENSP00000356868
ENST00000489443
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001558 regulation of cell growth
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007411 axon guidance
GO:0007417 central nervous system development
GO:0007420 brain development
GO:0010468 regulation of gene expression
GO:0021542 dentate gyrus development
GO:0021549 cerebellum development
GO:0021766 hippocampus development
GO:0021953 central nervous system neuron differentiation
GO:0030182 neuron differentiation
GO:0030901 midbrain development
GO:0045665 negative regulation of neuron differentiation
GO:0071542 dopaminergic neuron differentiation
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026686
View Gene Order
ENSBTAG00000012025
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.667312
RefSeq NM_001174069 NM_177398
HUGO
OMIM
CCDS CCDS1247
HPRD 02623
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca