Mus musculus Gene: Lmx1a
Summary
InnateDB Gene IDBG-203344.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lmx1a
Gene Name LIM homeobox transcription factor 1 alpha
Synonyms dr; dreher; Lmx1.1; sst;
Species Mus musculus
Ensembl Gene ENSMUSG00000026686
Encoded Proteins
LIM homeobox transcription factor 1 alpha
LIM homeobox transcription factor 1 alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000162761:
This gene encodes a homeodomain and LIM-domain containing protein. The encoded protein is a transcription factor that acts as a positive regulator of insulin gene transcription. This gene also plays a role in the development of dopamine producing neurons during embryogenesis. Mutations in this gene are associated with an increased risk of developing Parkinson's disease. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
This gene encodes a homeodomain and LIM-domain containing protein. The encoded protein is a transcription factor that acts as a positive regulator of insulin gene transcription. This gene also plays a role in the development of dopamine producing neurons during embryogenesis. Mutations in this gene are associated with an increased risk of developing Parkinson\'s disease. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:167689237-167848741
Strand Forward strand
Band H2.3
Transcripts
ENSMUST00000028003 ENSMUSP00000028003
ENSMUST00000111377 ENSMUSP00000107008
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001558 regulation of cell growth
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007411 axon guidance
GO:0007417 central nervous system development
GO:0007420 brain development
GO:0010468 regulation of gene expression
GO:0021542 dentate gyrus development
GO:0021549 cerebellum development
GO:0021766 hippocampus development
GO:0021953 central nervous system neuron differentiation
GO:0030182 neuron differentiation
GO:0030901 midbrain development
GO:0045665 negative regulation of neuron differentiation
GO:0071542 dopaminergic neuron differentiation
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt Q9JKU8
TrEMBL Q543W2
UniProt Splice Variant
Entrez Gene 110648
UniGene Mm.330081
RefSeq NM_033652 XM_006496611 XM_006496612
OMIM
CCDS CCDS15460
HPRD
IMGT
MGI ID MGI:1888519
MGI Symbol Lmx1a
EMBL AF226662 AK044944 BC109167 BC109168
GenPept AAF43012 AAI09168 AAI09169 BAC32153
RNA Seq Atlas 110648