Homo sapiens Gene: HOXA7
Summary
InnateDB Gene IDBG-10464.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HOXA7
Gene Name homeobox A7
Synonyms ANTP; HOX1; HOX1.1; HOX1A;
Species Homo sapiens
Ensembl Gene ENSG00000122592
Encoded Proteins
homeobox A7
homeobox A7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. For example, the encoded protein represses the transcription of differentiation-specific genes during keratinocyte proliferation, but this repression is then overcome by differentiation signals. This gene is highly similar to the antennapedia (Antp) gene of Drosophila. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:27153716-27157936
Strand Reverse strand
Band p15.2
Transcripts
ENST00000242159 ENSP00000242159
ENST00000523796
ENST00000519842 ENSP00000428563
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0008134 transcription factor binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001525 angiogenesis
GO:0001953 negative regulation of cell-matrix adhesion
GO:0002686 negative regulation of leukocyte migration
GO:0006351 transcription, DNA-templated
GO:0009952 anterior/posterior pattern specification
GO:0045617 negative regulation of keratinocyte differentiation
GO:0045656 negative regulation of monocyte differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048704 embryonic skeletal system morphogenesis
GO:0048863 stem cell differentiation
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
Keratinocyte differentiation [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.626796 Hs.660918
RefSeq NM_006896
HUGO
OMIM
CCDS CCDS5408
HPRD 00838
IMGT
EMBL
GenPept
RNA Seq Atlas