InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: HOXA7

Summary

InnateDB Gene

IDBG-10464.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HOXA7

Gene Name

homeobox A7

Synonyms

ANTP; HOX1; HOX1.1; HOX1A

Species

Homo sapiens

Ensembl Gene

ENSG00000122592

Encoded Proteins

IDBP-10466

homeobox A7

IDBP-481843

homeobox A7

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. For example, the encoded protein represses the transcription of differentiation-specific genes during keratinocyte proliferation, but this repression is then overcome by differentiation signals. This gene is highly similar to the antennapedia (Antp) gene of Drosophila. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:27153716-27157936

Strand

Reverse strand

Band

p15.2

Transcripts

ENST00000242159	ENSP00000242159
ENST00000523796
ENST00000519842	ENSP00000428563

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0008134	transcription factor binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001525	angiogenesis
GO:0001953	negative regulation of cell-matrix adhesion
GO:0002686	negative regulation of leukocyte migration
GO:0006351	transcription, DNA-templated
GO:0009952	anterior/posterior pattern specification
GO:0045617	negative regulation of keratinocyte differentiation
GO:0045656	negative regulation of monocyte differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048704	embryonic skeletal system morphogenesis
GO:0048863	stem cell differentiation

Cellular Component

GO:0005634

nucleus

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000038236

View Gene Order

ENSBTAG00000001455

Not yet available

Pathways

NETPATH

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

P31268

TrEMBL

E5RHM9

UniProt Splice Variant

Entrez Gene

3204

UniGene

Hs.626796 Hs.660918

RefSeq

NM_006896

HUGO

HGNC:5108

OMIM

142950

CCDS

CCDS5408

HPRD

IMGT

EMBL

AC004080 AF026397 AF032095 AJ005814 CH236948 CH471073 U92543 X84803 X84804

GenPept

AAB94604 AAD00727 AAD01939 CAA06713 CAA59270 EAL24221 EAW93877

RNA Seq Atlas

3204