InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Hoxa7

Summary

InnateDB Gene

IDBG-147979.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hoxa7

Gene Name

homeobox A7

Synonyms

AV118143; Hox-1.1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000038236

Encoded Proteins

IDBP-147981

homeobox A7

IDBP-619666

homeobox A7

IDBP-619668

homeobox A7

IDBP-789555

homeobox A7

IDBP-789554

homeobox A7

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000122592:
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. For example, the encoded protein represses the transcription of differentiation-specific genes during keratinocyte proliferation, but this repression is then overcome by differentiation signals. This gene is highly similar to the antennapedia (Antp) gene of Drosophila. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:52214491-52221854

Strand

Reverse strand

Band

Transcripts

ENSMUST00000048715	ENSMUSP00000048648
ENSMUST00000153280	ENSMUSP00000134641
ENSMUST00000134367	ENSMUSP00000134610
ENSMUST00000140316	ENSMUSP00000138790
ENSMUST00000150041	ENSMUSP00000140519

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	2 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0008134	transcription factor binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001525	angiogenesis
GO:0001953	negative regulation of cell-matrix adhesion
GO:0002686	negative regulation of leukocyte migration
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0009952	anterior/posterior pattern specification
GO:0045617	negative regulation of keratinocyte differentiation
GO:0045656	negative regulation of monocyte differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048704	embryonic skeletal system morphogenesis
GO:0048863	stem cell differentiation

Cellular Component

GO:0005634

nucleus

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000122592

View Gene Order

ENSBTAG00000001455

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.294826 Mm.486523

RefSeq

NM_010455 XM_006505609 XM_006505610 XM_006505612

OMIM

CCDS

CCDS20145

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas