Homo sapiens Gene: SELP
Summary
InnateDB Gene IDBG-104675.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SELP
Gene Name selectin P (granule membrane protein 140kDa, antigen CD62)
Synonyms CD62; CD62P; GMP140; GRMP; LECAM3; PADGEM; PSEL;
Species Homo sapiens
Ensembl Gene ENSG00000174175
Encoded Proteins
selectin P (granule membrane protein 140kDa, antigen CD62)
selectin P (granule membrane protein 140kDa, antigen CD62)
selectin P (granule membrane protein 140kDa, antigen CD62)
selectin P (granule membrane protein 140kDa, antigen CD62)
selectin P (granule membrane protein 140kDa, antigen CD62)
selectin P (granule membrane protein 140kDa, antigen CD62)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:169588849-169630193
Strand Reverse strand
Band q24.2
Transcripts
ENST00000367795 ENSP00000356769
ENST00000263686 ENSP00000263686
ENST00000367788 ENSP00000356762
ENST00000367786 ENSP00000356760
ENST00000426706 ENSP00000391694
ENST00000458599 ENSP00000399368
ENST00000466167
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001530 lipopolysaccharide binding
GO:0001948 glycoprotein binding
GO:0005515 protein binding
GO:0008201 heparin binding
GO:0030246 carbohydrate binding
GO:0033691 sialic acid binding
GO:0042806 fucose binding
GO:0043208 glycosphingolipid binding
GO:0048306 calcium-dependent protein binding
GO:0070492 oligosaccharide binding
Biological Process
GO:0002576 platelet degranulation
GO:0002687 positive regulation of leukocyte migration
GO:0006954 inflammatory response
GO:0007155 cell adhesion
GO:0007157 heterophilic cell-cell adhesion
GO:0007159 leukocyte cell-cell adhesion
GO:0007596 blood coagulation
GO:0010572 positive regulation of platelet activation
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0030168 platelet activation
GO:0032496 response to lipopolysaccharide
GO:0033623 regulation of integrin activation
GO:0050829 defense response to Gram-negative bacterium
GO:0050900 leukocyte migration
GO:0050901 leukocyte tethering or rolling
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0031088 platelet dense granule membrane
GO:0031092 platelet alpha granule membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Platelet degranulation pathway
Platelet activation, signaling and aggregation pathway
Response to elevated platelet cytosolic Ca2+ pathway
Cell surface interactions at the vascular wall pathway
Hemostasis pathway
KEGG
Cell adhesion molecules (CAMs) pathway
Malaria pathway
Staphylococcus aureus infection pathway
INOH
PID BIOCARTA
PID NCI
IL4-mediated signaling events
amb2 Integrin signaling
Cross-References
SwissProt P16109
TrEMBL A0A024R8Y9 Q6ULR6
UniProt Splice Variant
Entrez Gene 6403
UniGene Hs.73800
RefSeq NM_003005 XM_005245435 XM_005245436 XM_005245438 XM_005245440
HUGO HGNC:10721
OMIM 173610
CCDS CCDS1282
HPRD 01433
IMGT
EMBL AF542391 AL022146 AY367063 CH471067 M25322 M60217 M60218 M60219 M60222 M60223 M60224 M60225 M60226 M60227 M60228 M60229 M60231 M60232 M60233 M60234 Z99572
GenPept AAA35910 AAA35911 AAN06828 AAQ67703 CAI22753 CAI23058 EAW90851 EAW90853
RNA Seq Atlas 6403