Homo sapiens Gene: FMO2
Summary
InnateDB Gene IDBG-104776.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FMO2
Gene Name flavin containing monooxygenase 2 (non-functional)
Synonyms FMO1B1;
Species Homo sapiens
Ensembl Gene ENSG00000094963
Encoded Proteins
flavin containing monooxygenase 2 (non-functional)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The flavin-containing monooxygenases are NADPH-dependent enzymes that catalyze the oxidation of many drugs and xenobiotics. In most mammals, there is a flavin-containing monooxygenase that catalyzes the N-oxidation of some primary alkylamines through an N-hydroxylamine intermediate. However, in humans, this enzyme is truncated and is probably rapidly degraded. The protein encoded by this gene represents the truncated form and apparently has no catalytic activity. A functional allele found in African Americans has been reported, but no sequence evidence has been deposited to support the finding. This gene is found in a cluster with the FMO1, FMO3, and FMO4 genes on chromosome 1. [provided by RefSeq, Jul 2009]
This gene encodes a flavin-containing monooxygenase family member. It is an NADPH-dependent enzyme that catalyzes the N-oxidation of some primary alkylamines through an N-hydroxylamine intermediate. However, some human populations contain an allele (FMO2*2A) with a premature stop codon, resulting in a protein that is C-terminally-truncated, has no catalytic activity, and is likely degraded rapidly. This gene is found in a cluster with other related family members on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:171185208-171211230
Strand Forward strand
Band q24.3
Transcripts
ENST00000209929 ENSP00000209929
ENST00000462643
ENST00000489354
ENST00000493513
ENST00000483192
ENST00000488431
ENST00000529935
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004497 monooxygenase activity
GO:0004499 N,N-dimethylaniline monooxygenase activity
GO:0016491 oxidoreductase activity
GO:0050660 flavin adenine dinucleotide binding
GO:0050661 NADP binding
Biological Process
GO:0006082 organic acid metabolic process
GO:0006739 NADP metabolic process
GO:0006805 xenobiotic metabolic process
GO:0009404 toxin metabolic process
GO:0017144 drug metabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
GO:0070995 NADPH oxidation
GO:0072592 oxygen metabolic process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
FMO oxidises nucleophiles pathway
Metabolism pathway
Biological oxidations pathway
Phase 1 - Functionalization of compounds pathway
KEGG
Drug metabolism pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q99518
TrEMBL B4E2Q9
UniProt Splice Variant
Entrez Gene 2327
UniGene Hs.144912 Hs.610163 Hs.623040
RefSeq NM_001460
HUGO HGNC:3770
OMIM 603955
CCDS CCDS1293
HPRD 04903
IMGT
EMBL AK304385 AL021026 AY916056 BC005894 BT006979 CH471067 Y09267
GenPept AAH05894 AAP35625 AAW82431 BAG65221 CAA15910 CAA70462 EAW90889
RNA Seq Atlas 2327