InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: FMO2

Summary

InnateDB Gene

IDBG-632113.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FMO2

Gene Name

dimethylaniline monooxygenase

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000002974

Encoded Proteins

IDBP-683712

dimethylaniline monooxygenase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000094963:
The flavin-containing monooxygenases are NADPH-dependent enzymes that catalyze the oxidation of many drugs and xenobiotics. In most mammals, there is a flavin-containing monooxygenase that catalyzes the N-oxidation of some primary alkylamines through an N-hydroxylamine intermediate. However, in humans, this enzyme is truncated and is probably rapidly degraded. The protein encoded by this gene represents the truncated form and apparently has no catalytic activity. A functional allele found in African Americans has been reported, but no sequence evidence has been deposited to support the finding. This gene is found in a cluster with the FMO1, FMO3, and FMO4 genes on chromosome 1. [provided by RefSeq, Jul 2009]
This gene encodes a flavin-containing monooxygenase family member. It is an NADPH-dependent enzyme that catalyzes the N-oxidation of some primary alkylamines through an N-hydroxylamine intermediate. However, some human populations contain an allele (FMO2*2A) with a premature stop codon, resulting in a protein that is C-terminally-truncated, has no catalytic activity, and is likely degraded rapidly. This gene is found in a cluster with other related family members on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:39612586-39656811

Strand

Forward strand

Band

Transcripts

ENSBTAT00000003873

ENSBTAP00000003873

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004497	monooxygenase activity
GO:0004499	N,N-dimethylaniline monooxygenase activity
GO:0016491	oxidoreductase activity
GO:0050660	flavin adenine dinucleotide binding
GO:0050661	NADP binding

Biological Process

GO:0006082	organic acid metabolic process
GO:0006739	NADP metabolic process
GO:0006805	xenobiotic metabolic process
GO:0009404	toxin metabolic process
GO:0017144	drug metabolic process
GO:0055114	oxidation-reduction process
GO:0070995	NADPH oxidation
GO:0072592	oxygen metabolic process

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0031090	organelle membrane
GO:0043231	intracellular membrane-bounded organelle