Homo sapiens Gene: DNM3
Summary
InnateDB Gene IDBG-104822.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DNM3
Gene Name dynamin 3
Synonyms Dyna III;
Species Homo sapiens
Ensembl Gene ENSG00000197959
Encoded Proteins
dynamin 3
dynamin 3
dynamin 3
dynamin 3
dynamin 3
dynamin 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Members of the dynamin family, such as DNM3, possess mechanochemical properties involved in actin-membrane processes, predominantly in membrane budding (Orth and McNiven, 2003 [PubMed 12517701]).[supplied by OMIM, Mar 2008]
This gene encodes a member of a family of guanosine triphosphate (GTP)-binding proteins that associate with microtubules and are involved in vesicular transport. The encoded protein functions in the development of megakaryocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:171841498-172418466
Strand Forward strand
Band q24.3
Transcripts
ENST00000355305 ENSP00000347457
ENST00000367733 ENSP00000356707
ENST00000367731 ENSP00000356705
ENST00000520906 ENSP00000429701
ENST00000523513 ENSP00000429416
ENST00000485254 ENSP00000429165
ENST00000491124
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
Biological Process
GO:0006184 GTP catabolic process
GO:0006897 endocytosis
GO:0007416 synapse assembly
GO:0046847 filopodium assembly
Cellular Component
GO:0005739 mitochondrion
GO:0005874 microtubule
GO:0014069 postsynaptic density
GO:0043197 dendritic spine
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
MHC class II antigen presentation pathway
Developmental Biology pathway
Signalling by NGF pathway
Innate Immune System pathway
Toll-Like Receptors Cascades pathway
Axon guidance pathway
Signal Transduction pathway
Recycling pathway of L1 pathway
Adaptive Immune System pathway
Immune System pathway
NGF signalling via TRKA from the plasma membrane pathway
Retrograde neurotrophin signalling pathway
L1CAM interactions pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
KEGG
Endocytosis pathway
Bacterial invasion of epithelial cells pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9UQ16
TrEMBL
UniProt Splice Variant
Entrez Gene 26052
UniGene Hs.654775 Hs.675165 Hs.685968
RefSeq NM_001278252 NM_015569 NM_001136127 XM_005245081
HUGO HGNC:29125
OMIM 611445
CCDS CCDS60356 CCDS44276
HPRD 13241
IMGT
EMBL AB020627 AL031864 AL121984 AL133514 AL136712 AL137157 AL445990 AL512843 BC064546 CH471067 Z97195
GenPept AAH64546 BAA74843 CAB66647 CAH69969 CAH69970 CAH71040 CAH71041 CAH71951 CAH71952 CAH74079 CAH74080 CAI19054 CAI19055 CAI19211 CAI19212 CAI22007 CAI22008 EAW90918
RNA Seq Atlas 26052