InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DNM3

Summary

InnateDB Protein

IDBP-104832.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DNM3

Protein Name

dynamin 3

Synonyms

Dyna III;

Species

Homo sapiens

Ensembl Protein

ENSP00000356705

InnateDB Gene

IDBG-104822 (DNM3)

Protein Structure

UniProt Annotation

Function

Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000305}. Cytoplasm, cytoskeleton {ECO:0000305}. Note=Microtubule-associated. {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006897	endocytosis
GO:0007416	synapse assembly
GO:0046847	filopodium assembly

Cellular Component

GO:0005739	mitochondrion
GO:0005874	microtubule
GO:0014069	postsynaptic density
GO:0043197	dendritic spine
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000375 Dynamin central domain
IPR001401 Dynamin, GTPase domain
IPR001849 Pleckstrin homology domain
IPR003130 Dynamin GTPase effector
IPR022812 Dynamin superfamily
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF01031
PF00350
PF00169
PF02212

PRINTS

PR00195

PIRSF

SMART

SM00053
SM00233
SM00302

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt