Version 5.4
Homo sapiens Gene: TNFSF4
Summary
InnateDB Gene IDBG-104864.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNFSF4
Gene Name tumor necrosis factor (ligand) superfamily, member 4
Synonyms CD134L; CD252; GP34; OX-40L; OX4OL; TXGP1
Species Homo sapiens
Ensembl Gene ENSG00000117586
Encoded Proteins
IDBP-104866
tumor necrosis factor (ligand) superfamily, member 4
IDBP-104868
tumor necrosis factor (ligand) superfamily, member 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 26564814
[Mus musculus] Invariant natural killer T cell activation induced by mast cells exposed to alpha-galactosylceramide is regulated by costimulatory molecules Cd48 and Tnfsf4.
Entrez Gene
Summary The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF4/OX4. It is found to be involved in T cell antigen-presenting cell (APC) interactions. In surface Ig- and CD40-stimulated B cells, this cytokine along with CD70 has been shown to provide CD28-independent costimulatory signals to T cells. This protein and its receptor are reported to directly mediate adhesion of activated T cells to vascular endothelial cells. [provided by RefSeq, Jul 2008]
This gene encodes a cytokine of the tumor necrosis factor (TNF) ligand family. The encoded protein functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells. Polymorphisms in this gene have been associated with Sjogren\'s syndrome and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:173183734-173207313
Strand Reverse strand
Band q25.1
Transcripts
ENST00000281834 ENSP00000281834
ENST00000367718 ENSP00000356691
ENST00000488053
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005125 cytokine activity
GO:0005164 tumor necrosis factor receptor binding
GO:0005515 protein binding
GO:0032813 tumor necrosis factor receptor superfamily binding
Biological Process
GO:0001816 cytokine production
GO:0002215 defense response to nematode
GO:0002526 acute inflammatory response
GO:0002726 positive regulation of T cell cytokine production
GO:0002819 regulation of adaptive immune response
GO:0002830 positive regulation of type 2 immune response
GO:0002891 positive regulation of immunoglobulin mediated immune response
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007165 signal transduction
GO:0008203 cholesterol metabolic process
GO:0008284 positive regulation of cell proliferation
GO:0009615 response to virus
GO:0032689 negative regulation of interferon-gamma production
GO:0032700 negative regulation of interleukin-17 production
GO:0032729 positive regulation of interferon-gamma production
GO:0032733 positive regulation of interleukin-10 production
GO:0032735 positive regulation of interleukin-12 production
GO:0032736 positive regulation of interleukin-13 production
GO:0032743 positive regulation of interleukin-2 production
GO:0032753 positive regulation of interleukin-4 production
GO:0032755 positive regulation of interleukin-6 production
GO:0035709 memory T cell activation
GO:0035712 T-helper 2 cell activation
GO:0035713 response to nitrogen dioxide
GO:0035714 cellular response to nitrogen dioxide
GO:0035783 CD4-positive, alpha-beta T cell costimulation
GO:0042098 T cell proliferation
GO:0042104 positive regulation of activated T cell proliferation
GO:0043372 positive regulation of CD4-positive, alpha-beta T cell differentiation
GO:0043382 positive regulation of memory T cell differentiation
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045590 negative regulation of regulatory T cell differentiation
GO:0045626 negative regulation of T-helper 1 cell differentiation
GO:0045630 positive regulation of T-helper 2 cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0046641 positive regulation of alpha-beta T cell proliferation
GO:0050710 negative regulation of cytokine secretion
GO:0050727 regulation of inflammatory response
GO:0050729 positive regulation of inflammatory response
GO:0050871 positive regulation of B cell activation
GO:0051024 positive regulation of immunoglobulin secretion
GO:0071222 cellular response to lipopolysaccharide
GO:0071380 cellular response to prostaglandin E stimulus
GO:0071954 chemokine (C-C motif) ligand 11 production
GO:1900281 positive regulation of CD4-positive, alpha beta T cell costimulation
GO:2000525 positive regulation of T cell costimulation
GO:2000568 positive regulation of memory T cell activation
GO:2000570 positive regulation of T-helper 2 cell activation
GO:2000572 positive regulation of interleukin-4-dependent isotype switching to IgE isotypes
Cellular Component
GO:0005615 extracellular space
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000026700
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.181097
RefSeq NM_001297562 NM_003326 XM_005245475
HUGO
OMIM
CCDS CCDS1306 CCDS72985
HPRD 04668
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca