Homo sapiens Gene: TNFSF4
Summary
InnateDB Gene IDBG-104864.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNFSF4
Gene Name tumor necrosis factor (ligand) superfamily, member 4
Synonyms CD134L; CD252; GP34; OX-40L; OX4OL; TXGP1;
Species Homo sapiens
Ensembl Gene ENSG00000117586
Encoded Proteins
tumor necrosis factor (ligand) superfamily, member 4
tumor necrosis factor (ligand) superfamily, member 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Invariant natural killer T cell activation induced by mast cells exposed to alpha-galactosylceramide is regulated by costimulatory molecules Cd48 and Tnfsf4.
Entrez Gene
Summary The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF4/OX4. It is found to be involved in T cell antigen-presenting cell (APC) interactions. In surface Ig- and CD40-stimulated B cells, this cytokine along with CD70 has been shown to provide CD28-independent costimulatory signals to T cells. This protein and its receptor are reported to directly mediate adhesion of activated T cells to vascular endothelial cells. [provided by RefSeq, Jul 2008]
This gene encodes a cytokine of the tumor necrosis factor (TNF) ligand family. The encoded protein functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells. Polymorphisms in this gene have been associated with Sjogren\'s syndrome and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:173183734-173207313
Strand Reverse strand
Band q25.1
Transcripts
ENST00000281834 ENSP00000281834
ENST00000367718 ENSP00000356691
ENST00000488053
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005125 cytokine activity
GO:0005164 tumor necrosis factor receptor binding
GO:0005515 protein binding
GO:0032813 tumor necrosis factor receptor superfamily binding
Biological Process
GO:0001816 cytokine production
GO:0002215 defense response to nematode
GO:0002526 acute inflammatory response
GO:0002726 positive regulation of T cell cytokine production
GO:0002819 regulation of adaptive immune response
GO:0002830 positive regulation of type 2 immune response
GO:0002891 positive regulation of immunoglobulin mediated immune response
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007165 signal transduction
GO:0008203 cholesterol metabolic process
GO:0008284 positive regulation of cell proliferation
GO:0009615 response to virus
GO:0032689 negative regulation of interferon-gamma production
GO:0032700 negative regulation of interleukin-17 production
GO:0032729 positive regulation of interferon-gamma production
GO:0032733 positive regulation of interleukin-10 production
GO:0032735 positive regulation of interleukin-12 production
GO:0032736 positive regulation of interleukin-13 production
GO:0032743 positive regulation of interleukin-2 production
GO:0032753 positive regulation of interleukin-4 production
GO:0032755 positive regulation of interleukin-6 production
GO:0035709 memory T cell activation
GO:0035712 T-helper 2 cell activation
GO:0035713 response to nitrogen dioxide
GO:0035714 cellular response to nitrogen dioxide
GO:0035783 CD4-positive, alpha-beta T cell costimulation
GO:0042098 T cell proliferation
GO:0042104 positive regulation of activated T cell proliferation
GO:0043372 positive regulation of CD4-positive, alpha-beta T cell differentiation
GO:0043382 positive regulation of memory T cell differentiation
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045590 negative regulation of regulatory T cell differentiation
GO:0045626 negative regulation of T-helper 1 cell differentiation
GO:0045630 positive regulation of T-helper 2 cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0046641 positive regulation of alpha-beta T cell proliferation
GO:0050710 negative regulation of cytokine secretion
GO:0050727 regulation of inflammatory response
GO:0050729 positive regulation of inflammatory response
GO:0050871 positive regulation of B cell activation
GO:0051024 positive regulation of immunoglobulin secretion
GO:0071222 cellular response to lipopolysaccharide
GO:0071380 cellular response to prostaglandin E stimulus
GO:0071954 chemokine (C-C motif) ligand 11 production
GO:1900281 positive regulation of CD4-positive, alpha beta T cell costimulation
GO:2000525 positive regulation of T cell costimulation
GO:2000568 positive regulation of memory T cell activation
GO:2000570 positive regulation of T-helper 2 cell activation
GO:2000572 positive regulation of interleukin-4-dependent isotype switching to IgE isotypes
Cellular Component
GO:0005615 extracellular space
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
KEGG
Cytokine-cytokine receptor interaction pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.181097
RefSeq NM_001297562 NM_003326 XM_005245475
HUGO
OMIM
CCDS CCDS1306 CCDS72985
HPRD 04668
IMGT
EMBL
GenPept
RNA Seq Atlas