InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TNFSF4

Summary

InnateDB Protein

IDBP-104866.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNFSF4

Protein Name

tumor necrosis factor (ligand) superfamily, member 4

Synonyms

CD134L; CD252; GP34; OX-40L; OX4OL; TXGP1;

Species

Homo sapiens

Ensembl Protein

ENSP00000281834

InnateDB Gene

IDBG-104864 (TNFSF4)

Protein Structure

UniProt Annotation

Function

Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.

Subcellular Localization

Membrane; Single-pass type II membrane protein.

Disease Associations

Systemic lupus erythematosus (SLE) [MIM:152700]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. {ECO:0000269PubMed:18059267}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. The upstream region of TNFSF4 contains a single risk haplotype for SLE, which is correlated with increased expression of both cell-surface TNFSF4 and TNFSF4 transcripts. Increased levels of TNFSF4 are thought to augment T-cell-APC interaction and the functional consequences of T-cell activation, thereby destabilizing peripheral tolerance.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005125	cytokine activity
GO:0005164	tumor necrosis factor receptor binding
GO:0005515	protein binding
GO:0032813	tumor necrosis factor receptor superfamily binding

Biological Process

GO:0001816	cytokine production
GO:0002215	defense response to nematode
GO:0002526	acute inflammatory response
GO:0002726	positive regulation of T cell cytokine production
GO:0002819	regulation of adaptive immune response
GO:0002830	positive regulation of type 2 immune response
GO:0002891	positive regulation of immunoglobulin mediated immune response
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007165	signal transduction
GO:0008203	cholesterol metabolic process
GO:0008284	positive regulation of cell proliferation
GO:0009615	response to virus
GO:0032689	negative regulation of interferon-gamma production
GO:0032700	negative regulation of interleukin-17 production
GO:0032729	positive regulation of interferon-gamma production
GO:0032733	positive regulation of interleukin-10 production
GO:0032735	positive regulation of interleukin-12 production
GO:0032736	positive regulation of interleukin-13 production
GO:0032743	positive regulation of interleukin-2 production
GO:0032753	positive regulation of interleukin-4 production
GO:0032755	positive regulation of interleukin-6 production
GO:0035709	memory T cell activation
GO:0035712	T-helper 2 cell activation
GO:0035713	response to nitrogen dioxide
GO:0035714	cellular response to nitrogen dioxide
GO:0035783	CD4-positive, alpha-beta T cell costimulation
GO:0042098	T cell proliferation
GO:0042104	positive regulation of activated T cell proliferation
GO:0043372	positive regulation of CD4-positive, alpha-beta T cell differentiation
GO:0043382	positive regulation of memory T cell differentiation
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045590	negative regulation of regulatory T cell differentiation
GO:0045626	negative regulation of T-helper 1 cell differentiation
GO:0045630	positive regulation of T-helper 2 cell differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0046641	positive regulation of alpha-beta T cell proliferation
GO:0050710	negative regulation of cytokine secretion
GO:0050727	regulation of inflammatory response
GO:0050729	positive regulation of inflammatory response
GO:0050871	positive regulation of B cell activation
GO:0051024	positive regulation of immunoglobulin secretion
GO:0071222	cellular response to lipopolysaccharide
GO:0071380	cellular response to prostaglandin E stimulus
GO:0071954	chemokine (C-C motif) ligand 11 production
GO:1900281	positive regulation of CD4-positive, alpha beta T cell costimulation
GO:2000525	positive regulation of T cell costimulation
GO:2000568	positive regulation of memory T cell activation
GO:2000570	positive regulation of T-helper 2 cell activation
GO:2000572	positive regulation of interleukin-4-dependent isotype switching to IgE isotypes