Version 5.4
Homo sapiens Gene: LHX4
Summary
InnateDB Gene IDBG-105169.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LHX4
Gene Name LIM homeobox 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000121454
Encoded Proteins
IDBP-105171
LIM homeobox 4
IDBP-583849
LIM homeobox 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor involved in the control of differentiation and development of the pituitary gland. Mutations in this gene cause combined pituitary hormone deficiency 4. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:180230286-180278982
Strand Forward strand
Band q25.2
Transcripts
ENST00000263726 ENSP00000263726
ENST00000558139
ENST00000561113 ENSP00000452783
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001890 placenta development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0008045 motor neuron axon guidance
GO:0009887 organ morphogenesis
GO:0021526 medial motor column neuron differentiation
GO:0043066 negative regulation of apoptotic process
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026468
View Gene Order
ENSBTAG00000003992
Not yet available
Cross-References
SwissProt Q969G2
TrEMBL Q5RLJ1 Q5RLJ2 Q5RLJ3 Q96JP7
UniProt Splice Variant
Entrez Gene 89884
UniGene Hs.562134 Hs.658487
RefSeq NM_033343
HUGO HGNC:21734
OMIM 602146
CCDS CCDS1338
HPRD
IMGT
EMBL AB037683 AB055703 AB055704 AF179849 AF282899 AF405425 AF405426 AF405427 AF405428 AF405429 AF405430 AH011598 AL139141 AY053457 AY817172 AY817173 AY817174 BC011759
GenPept AAH11759 AAK69169 AAK70923 AAL07260 AAM19349 AAM91896 AAV67806 AAV67807 AAV67808 BAB62817 BAB62818 BAC01272 CAI19364
RNA Seq Atlas 89884

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca