Homo sapiens Gene: LAMC1
Summary
InnateDB Gene IDBG-105290.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LAMC1
Gene Name laminin, gamma 1 (formerly LAMB2)
Synonyms LAMB2;
Species Homo sapiens
Ensembl Gene ENSG00000135862
Encoded Proteins
laminin, gamma 1 (formerly LAMB2)
laminin, gamma 1 (formerly LAMB2)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), have a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 1. The gamma 1 chain, formerly thought to be a beta chain, contains structural domains similar to beta chains, however, lacks the short alpha region separating domains I and II. The structural organization of this gene also suggested that it had diverged considerably from the beta chain genes. Embryos of transgenic mice in which both alleles of the gamma 1 chain gene were inactivated by homologous recombination, lacked basement membranes, indicating that laminin, gamma 1 chain is necessary for laminin heterotrimer assembly. It has been inferred by analogy with the strikingly similar 3' UTR sequence in mouse laminin gamma 1 cDNA, that multiple polyadenylation sites are utilized in human to generate the 2 different sized mRNAs (5.5 and 7.5 kb) seen on Northern analysis. [provided by RefSeq, Aug 2011]
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), have a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 1. The gamma 1 chain, formerly thought to be a beta chain, contains structural domains similar to beta chains, however, lacks the short alpha region separating domains I and II. The structural organization of this gene also suggested that it had diverged considerably from the beta chain genes. Embryos of transgenic mice in which both alleles of the gamma 1 chain gene were inactivated by homologous recombination, lacked basement membranes, indicating that laminin, gamma 1 chain is necessary for laminin heterotrimer assembly. It has been inferred by analogy with the strikingly similar 3\' UTR sequence in mouse laminin gamma 1 cDNA, that multiple polyadenylation sites are utilized in human to generate the 2 different sized mRNAs (5.5 and 7.5 kb) seen on Northern analysis. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:183023460-183145592
Strand Forward strand
Band q25.3
Transcripts
ENST00000258341 ENSP00000258341
ENST00000484114 ENSP00000473583
ENST00000479499
ENST00000466964
ENST00000478064
ENST00000495918
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 31 [view]
Protein-Protein 30 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005201 extracellular matrix structural constituent
GO:0005515 protein binding
GO:0043208 glycosphingolipid binding
Biological Process
GO:0006461 protein complex assembly
GO:0007155 cell adhesion
GO:0007411 axon guidance
GO:0007492 endoderm development
GO:0016477 cell migration
GO:0022617 extracellular matrix disassembly
GO:0030198 extracellular matrix organization
GO:0031175 neuron projection development
GO:0031581 hemidesmosome assembly
GO:0034446 substrate adhesion-dependent cell spreading
GO:0050679 positive regulation of epithelial cell proliferation
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0005604 basement membrane
GO:0005605 basal lamina
GO:0005606 laminin-1 complex
GO:0005615 extracellular space
GO:0031012 extracellular matrix
GO:0043259 laminin-10 complex
GO:0043260 laminin-11 complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
Alpha6Beta4Integrin pathway
REACTOME
Developmental Biology pathway
Extracellular matrix organization pathway
Degradation of the extracellular matrix pathway
Axon guidance pathway
ECM proteoglycans pathway
Non-integrin membrane-ECM interactions pathway
L1CAM interactions pathway
Laminin interactions pathway
KEGG
Focal adhesion pathway
ECM-receptor interaction pathway
Prion diseases pathway
Toxoplasmosis pathway
Amoebiasis pathway
Pathways in cancer pathway
Small cell lung cancer pathway
INOH
PID BIOCARTA
Agrin in postsynaptic differentiation [Biocarta view]
PID NCI
Beta1 integrin cell surface interactions
Regulation of nuclear SMAD2/3 signaling
Alpha6 beta4 integrin-ligand interactions
Beta3 integrin cell surface interactions
Cross-References
SwissProt P11047
TrEMBL A0A024R972 R4GNC7
UniProt Splice Variant
Entrez Gene 3915
UniGene Hs.609663 Hs.694782 Hs.707459
RefSeq NM_002293
HUGO HGNC:6492
OMIM 150290
CCDS CCDS1351
HPRD
IMGT
EMBL AL354953 AL450304 CH471067 J03202 M27654 M55192 M55193 M55194 M55195 M55196 M55197 M55198 M55199 M55200 M55201 M55202 M55203 M55204 M55205 M55206 M55207 M55208 M55209 M55210 M55211 M55212 M55213 M55214 M55215 M55216 M55217 X13939
GenPept AAA59488 AAA59489 AAA59492 CAA32122 CAH70981 CAI14877 EAW91144 EAW91145
RNA Seq Atlas 3915