InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LAMC1

Summary

InnateDB Protein

IDBP-105292.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LAMC1

Protein Name

laminin, gamma 1 (formerly LAMB2)

Synonyms

LAMB2;

Species

Homo sapiens

Ensembl Protein

ENSP00000258341

InnateDB Gene

IDBG-105290 (LAMC1)

Protein Structure

UniProt Annotation

Function

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

Subcellular Localization

Secreted, extracellular space, extracellular matrix, basement membrane.

Disease Associations

Tissue Specificity

Found in the basement membranes (major component).

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	31 [view]
Protein-Protein	30 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005201	extracellular matrix structural constituent
GO:0005515	protein binding
GO:0043208	glycosphingolipid binding

Biological Process

GO:0006461	protein complex assembly
GO:0007155	cell adhesion
GO:0007411	axon guidance
GO:0007492	endoderm development
GO:0016477	cell migration
GO:0022617	extracellular matrix disassembly
GO:0030198	extracellular matrix organization
GO:0031175	neuron projection development
GO:0031581	hemidesmosome assembly
GO:0034446	substrate adhesion-dependent cell spreading
GO:0050679	positive regulation of epithelial cell proliferation

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005604	basement membrane
GO:0005605	basal lamina
GO:0005606	laminin-1 complex
GO:0005615	extracellular space
GO:0031012	extracellular matrix
GO:0043259	laminin-10 complex
GO:0043260	laminin-11 complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000034 Laminin B type IV
IPR000742 Epidermal growth factor-like domain
IPR002049 EGF-like, laminin
IPR008211 Laminin, N-terminal
IPR018031 Laminin B, subgroup

PFAM

PF00052
PF00008
PF00053
PF00055

PRINTS

PIRSF

SMART

SM00181
SM00180
SM00136
SM00281

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P11047