Homo sapiens Gene: TPR
Summary
InnateDB Gene IDBG-105409.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TPR
Gene Name translocated promoter region, nuclear basket protein
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000047410
Encoded Proteins
translocated promoter region (to activated MET oncogene)
translocated promoter region (to activated MET oncogene)
translocated promoter region, nuclear basket protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a large coiled-coil protein that forms intranuclear filaments attached to the inner surface of nuclear pore complexes (NPCs). The protein directly interacts with several components of the NPC. It is required for the nuclear export of mRNAs and some proteins. Oncogenic fusions of the 5' end of this gene with several different kinase genes occur in some neoplasias. [provided by RefSeq, Jul 2008]
This gene encodes a large coiled-coil protein that forms intranuclear filaments attached to the inner surface of nuclear pore complexes (NPCs). The protein directly interacts with several components of the NPC. It is required for the nuclear export of mRNAs and some proteins. Oncogenic fusions of the 5\' end of this gene with several different kinase genes occur in some neoplasias. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:186311652-186375693
Strand Reverse strand
Band q31.1
Transcripts
ENST00000367478 ENSP00000356448
ENST00000451586 ENSP00000408103
ENST00000467810
ENST00000492973
ENST00000481347
ENST00000491783
ENST00000469463
ENST00000474852
ENST00000613151 ENSP00000483425
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 78 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 78 [view]
Protein-Protein 75 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003682 chromatin binding
GO:0003729 mRNA binding
GO:0005487 nucleocytoplasmic transporter activity
GO:0005515 protein binding
GO:0015631 tubulin binding
GO:0031072 heat shock protein binding
GO:0042803 protein homodimerization activity
GO:0044822 poly(A) RNA binding
GO:0051019 mitogen-activated protein kinase binding
GO:0070840 dynein complex binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000189 MAPK import into nucleus
GO:0000278 mitotic cell cycle
GO:0005975 carbohydrate metabolic process
GO:0006404 RNA import into nucleus
GO:0006405 RNA export from nucleus
GO:0006606 protein import into nucleus
GO:0006999 nuclear pore organization
GO:0007067 mitotic nuclear division
GO:0007077 mitotic nuclear envelope disassembly
GO:0007094 mitotic spindle assembly checkpoint
GO:0008645 hexose transport
GO:0010827 regulation of glucose transport
GO:0010965 regulation of mitotic sister chromatid separation
GO:0015758 glucose transport
GO:0016032 viral process
GO:0019221 cytokine-mediated signaling pathway
GO:0031453 positive regulation of heterochromatin assembly
GO:0031990 mRNA export from nucleus in response to heat stress
GO:0034605 cellular response to heat
GO:0035457 cellular response to interferon-alpha
GO:0042307 positive regulation of protein import into nucleus
GO:0044281 small molecule metabolic process
GO:0045947 negative regulation of translational initiation
GO:0046827 positive regulation of protein export from nucleus
GO:0046832 negative regulation of RNA export from nucleus
GO:0055085 transmembrane transport
GO:0070849 response to epidermal growth factor
GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint
GO:0090316 positive regulation of intracellular protein transport
GO:1901673 regulation of spindle assembly involved in mitosis
Cellular Component
GO:0000776 kinetochore
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005643 nuclear pore
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005868 cytoplasmic dynein complex
GO:0019898 extrinsic component of membrane
GO:0031965 nuclear membrane
GO:0034399 nuclear periphery
GO:0042405 nuclear inclusion body
GO:0044615 nuclear pore nuclear basket
GO:0072686 mitotic spindle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Influenza Infection pathway
Interactions of Vpr with host cellular proteins pathway
Vpr-mediated nuclear import of PICs pathway
Myoclonic epilepsy of Lafora pathway
Antiviral mechanism by IFN-stimulated genes pathway
Glucose transport pathway
Hexose transport pathway
Cytokine Signaling in Immune system pathway
Metabolism of carbohydrates pathway
Late Phase of HIV Life Cycle pathway
Viral Messenger RNA Synthesis pathway
Transcriptional regulation by small RNAs pathway
Nuclear Pore Complex (NPC) Disassembly pathway
Influenza Viral RNA Transcription and Replication pathway
Interferon Signaling pathway
Cell Cycle pathway
Immune System pathway
Regulation of Glucokinase by Glucokinase Regulatory Protein pathway
M Phase pathway
HIV Life Cycle pathway
Mitotic Prophase pathway
Rev-mediated nuclear export of HIV RNA pathway
Cell Cycle, Mitotic pathway
HIV Infection pathway
ISG15 antiviral mechanism pathway
Influenza Life Cycle pathway
Nuclear import of Rev protein pathway
Metabolism pathway
Host Interactions of HIV factors pathway
SLC-mediated transmembrane transport pathway
Interactions of Rev with host cellular proteins pathway
Gene Expression pathway
Nuclear Envelope Breakdown pathway
Disease pathway
Glycogen storage diseases pathway
Regulatory RNA pathways pathway
KEGG
RNA transport pathway
Pathways in cancer pathway
Thyroid cancer pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL Q5SWX9
UniProt Splice Variant
Entrez Gene 7175
UniGene Hs.279640
RefSeq NM_003292 XM_005245471
HUGO HGNC:12017
OMIM 189940
CCDS CCDS41446
HPRD 08927
IMGT
EMBL AL133553 AL596220
GenPept
RNA Seq Atlas 7175