Version 5.4
Homo sapiens Gene: NEK7
Summary
InnateDB Gene IDBG-105595.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NEK7
Gene Name NIMA-related kinase 7
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000151414
Encoded Proteins
IDBP-105597
NIMA (never in mitosis gene a)-related kinase 7
IDBP-105599
NIMA (never in mitosis gene a)-related kinase 7
IDBP-246605
NIMA (never in mitosis gene a)-related kinase 7
IDBP-389844
NIMA (never in mitosis gene a)-related kinase 7
IDBP-592543
NIMA (never in mitosis gene a)-related kinase 7
IDBP-588008
NIMA (never in mitosis gene a)-related kinase 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary NIMA-related kinases share high amino acid sequence identity with the gene product of the Aspergillus nidulans 'never in mitosis A' gene, which controls initiation of mitosis.[supplied by OMIM, Jul 2002]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:198156963-198322420
Strand Forward strand
Band q31.3
Transcripts
ENST00000367385 ENSP00000356355
ENST00000367383 ENSP00000356353
ENST00000391974 ENSP00000375835
ENST00000442588 ENSP00000392745
ENST00000417895
ENST00000493790
ENST00000538004 ENSP00000444621
ENST00000544035 ENSP00000439095
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 4 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0046872 metal ion binding
Biological Process
GO:0000910 cytokinesis
GO:0006468 protein phosphorylation
GO:0007346 regulation of mitotic cell cycle
GO:0051225 spindle assembly
Cellular Component
GO:0000922 spindle pole
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0005874 microtubule
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026393
View Gene Order
ENSBTAG00000016943
Not yet available
Pathways
NETPATH
REACTOME
REACT_160122
Activation of NIMA Kinases NEK9, NEK6, NEK7 pathway
REACT_163931
Nuclear Pore Complex (NPC) Disassembly pathway
REACT_115566
Cell Cycle pathway
REACT_910
M Phase pathway
REACT_765
Mitotic Prophase pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_160255
Nuclear Envelope Breakdown pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL C9J1H8 F5H3U7
UniProt Splice Variant
Entrez Gene 140609
UniGene Hs.24119 Hs.732564
RefSeq NM_133494
HUGO HGNC:13386
OMIM 606848
CCDS CCDS1394
HPRD 06027
IMGT
EMBL AC093419 AC093561
GenPept
RNA Seq Atlas 140609

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca