Version 5.4
Homo sapiens Protein: NEK7
Summary
InnateDB Protein IDBP-105599.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NEK7
Protein Name NIMA (never in mitosis gene a)-related kinase 7
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000356353
InnateDB Gene IDBG-105595 (NEK7)
Protein Structure
UniProt Annotation
Function Protein kinase which plays an important role in mitotic cell cycle progression. Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis. Phosphorylates RPS6KB1. {ECO:0000269PubMed:17101132, ECO:0000269PubMed:17586473, ECO:0000269PubMed:19414596}.
Subcellular Localization Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Present at centrosome throughout the cell cycle. Also detected at spindle midzone of the anaphase cells and eventually concentrates at the midbody.
Disease Associations
Tissue Specificity Highly expressed in lung, muscle, testis, brain, heart, liver, leukocyte and spleen. Lower expression in ovary, prostate and kidney. No expression seen in small intestine. {ECO:0000269PubMed:11701951}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 4 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0046872 metal ion binding
Biological Process
GO:0000910 cytokinesis
GO:0006468 protein phosphorylation
GO:0007346 regulation of mitotic cell cycle
GO:0051225 spindle assembly
Cellular Component
GO:0000922 spindle pole
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0005874 microtubule
Protein Structure and Domains
PDB ID
InterPro IPR011009 Protein kinase-like domain
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TDX7
PhosphoSite PhosphoSite-Q8TDX7
TrEMBL F5H3U7
UniProt Splice Variant
Entrez Gene 140609
UniGene Hs.732564
RefSeq
HUGO HGNC:13386
OMIM 606848
CCDS
HPRD 06027
IMGT
EMBL AB062450 AC093419 AC093561 CH471067 CK819069
GenPept BAB85632 EAW91294

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca