Homo sapiens Gene: KLHL12
Summary
InnateDB Gene IDBG-105884.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KLHL12
Gene Name kelch-like 12 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000117153
Encoded Proteins
kelch-like 12 (Drosophila)
kelch-like 12 (Drosophila)
kelch-like 12 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 1:202891100-202928636
Strand Reverse strand
Band q32.1
Transcripts
ENST00000367261 ENSP00000356230
ENST00000367259 ENSP00000356228
ENST00000367258 ENSP00000356227
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
Experimentally validated
Total 35 [view]
Protein-Protein 35 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006513 protein monoubiquitination
GO:0006888 ER to Golgi vesicle-mediated transport
GO:0016055 Wnt signaling pathway
GO:0048208 COPII vesicle coating
Cellular Component
GO:0000139 Golgi membrane
GO:0030134 ER to Golgi transport vesicle
GO:0031463 Cul3-RING ubiquitin ligase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Signaling by WNT in cancer pathway
Signaling by Wnt pathway
degradation of DVL pathway
Signal Transduction pathway
TCF dependent signaling in response to WNT pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Disease pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Canonical Wnt signaling pathway
Cross-References
SwissProt Q53G59
TrEMBL
UniProt Splice Variant
Entrez Gene 59349
UniGene Hs.706793
RefSeq NM_021633 XM_005245403 XM_006711478
HUGO HGNC:19360
OMIM 614522
CCDS CCDS1429
HPRD 13925
IMGT
EMBL AC096632 AF190900 AK027656 AK223072 AK301791 BC003183 BC004175
GenPept AAG17175 AAH03183 AAH04175 BAB55271 BAD96792 BAH13554
RNA Seq Atlas 59349