Mus musculus Gene: Klhl12
Summary
InnateDB Gene IDBG-193821.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Klhl12
Gene Name kelch-like 12 (Drosophila)
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000026455
Encoded Proteins
kelch-like 12 (Drosophila)
kelch-like 12 (Drosophila)
kelch-like 12 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000117153:
Gene Information
Type Protein coding
Genomic Location Chromosome 1:134455531-134491018
Strand Forward strand
Band E4
Transcripts
ENSMUST00000027725 ENSMUSP00000027725
ENSMUST00000112232 ENSMUSP00000107851
ENSMUST00000116528 ENSMUSP00000112227
ENSMUST00000133721
ENSMUST00000141458
ENSMUST00000189981
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.
Predicted by orthology
Total 29 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0006513 protein monoubiquitination
GO:0006888 ER to Golgi vesicle-mediated transport
GO:0016055 Wnt signaling pathway
GO:0048208 COPII vesicle coating
Cellular Component
GO:0000139 Golgi membrane
GO:0030134 ER to Golgi transport vesicle
GO:0031463 Cul3-RING ubiquitin ligase complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Disease pathway
Signaling by Wnt pathway
Signaling by WNT in cancer pathway
degradation of DVL pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
TCF dependent signaling in response to WNT pathway
Signal Transduction pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Signaling by WNT in cancer pathway
Signaling by Wnt pathway
degradation of DVL pathway
Signal Transduction pathway
TCF dependent signaling in response to WNT pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Disease pathway
Signaling by Wnt pathway
Signaling by WNT in cancer pathway
TCF dependent signaling in response to WNT pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Signal Transduction pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
degradation of DVL pathway
Disease pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Canonical Wnt signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.490400 Mm.87398
RefSeq NM_153128 XM_006529560 XM_006529561
OMIM
CCDS CCDS35715
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas