Homo sapiens Gene: ADIPOR1
Summary
InnateDB Gene IDBG-105893.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADIPOR1
Gene Name adiponectin receptor 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000159346
Encoded Proteins
adiponectin receptor 1
adiponectin receptor 1
adiponectin receptor 1
adiponectin receptor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein which acts as a receptor for adiponectin, a hormone secreted by adipocytes which regulates fatty acid catabolism and glucose levels. Binding of adiponectin to the encoded protein results in activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and insulin sensitivity. A pseudogene of this gene is located on chromosome 14. [provided by RefSeq, Jan 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:202940823-202958572
Strand Reverse strand
Band q32.1
Transcripts
ENST00000340990 ENSP00000341785
ENST00000367254 ENSP00000356223
ENST00000417068 ENSP00000402178
ENST00000426229 ENSP00000392946
ENST00000495562
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 9 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0042562 hormone binding
GO:0042802 identical protein binding
GO:0046982 protein heterodimerization activity
GO:0055100 adiponectin binding
Biological Process
GO:0009755 hormone-mediated signaling pathway
GO:0019395 fatty acid oxidation
GO:0030308 negative regulation of cell growth
GO:0033210 leptin-mediated signaling pathway
GO:0033211 adiponectin-activated signaling pathway
GO:0046427 positive regulation of JAK-STAT cascade
GO:0046628 positive regulation of insulin receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
KEGG
Adipocytokine signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL F8W782
UniProt Splice Variant
Entrez Gene 51094
UniGene Hs.713729 Hs.743483
RefSeq NM_001290553 NM_001290557 NM_001290629 NM_015999 XM_006711360 XM_006711361
HUGO HGNC:24040
OMIM 607945
CCDS CCDS1430
HPRD 06402
IMGT
EMBL AC096632
GenPept
RNA Seq Atlas 51094