Version 5.4
Homo sapiens Gene: ADIPOR1
Summary
InnateDB Gene IDBG-105893.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADIPOR1
Gene Name adiponectin receptor 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000159346
Encoded Proteins
IDBP-105895
adiponectin receptor 1
IDBP-105897
adiponectin receptor 1
IDBP-389903
adiponectin receptor 1
IDBP-389904
adiponectin receptor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein which acts as a receptor for adiponectin, a hormone secreted by adipocytes which regulates fatty acid catabolism and glucose levels. Binding of adiponectin to the encoded protein results in activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and insulin sensitivity. A pseudogene of this gene is located on chromosome 14. [provided by RefSeq, Jan 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:202940823-202958572
Strand Reverse strand
Band q32.1
Transcripts
ENST00000340990 ENSP00000341785
ENST00000367254 ENSP00000356223
ENST00000417068 ENSP00000402178
ENST00000426229 ENSP00000392946
ENST00000495562
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 9 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0042562 hormone binding
GO:0042802 identical protein binding
GO:0046982 protein heterodimerization activity
GO:0055100 adiponectin binding
Biological Process
GO:0009755 hormone-mediated signaling pathway
GO:0019395 fatty acid oxidation
GO:0030308 negative regulation of cell growth
GO:0033210 leptin-mediated signaling pathway
GO:0033211 adiponectin-activated signaling pathway
GO:0046427 positive regulation of JAK-STAT cascade
GO:0046628 positive regulation of insulin receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026457
View Gene Order
ENSBTAG00000009727
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04920
Adipocytokine signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt Q96A54
TrEMBL C9J0W7 C9JNM5 F8W782
UniProt Splice Variant
Entrez Gene 51094
UniGene Hs.713729 Hs.743483
RefSeq NM_001290553 NM_001290557 NM_001290629 NM_015999 XM_006711360 XM_006711361
HUGO HGNC:24040
OMIM 607945
CCDS CCDS1430
HPRD
IMGT
EMBL AC096632 AF125179 AF151803 AK001484 AK222503 AY424279 BC001594 BC010743 CH471067
GenPept AAD34040 AAH01594 AAH10743 AAQ13552 AAR08367 BAD96223 BAG50922 EAW91450
RNA Seq Atlas 51094

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca