InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ADIPOR1

Summary

InnateDB Protein

IDBP-105895.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADIPOR1

Protein Name

adiponectin receptor 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000341785

InnateDB Gene

IDBG-105893 (ADIPOR1)

Protein Structure

UniProt Annotation

Function

Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some high-affinity receptor for globular adiponectin but low-affinity receptor for full-length adiponectin. {ECO:0000269PubMed:12802337}.

Subcellular Localization

Membrane {ECO:0000269PubMed:12802337}; Multi-pass membrane protein {ECO:0000269PubMed:12802337}. Note=Localized to the cell membrane and intracellular organelles.

Disease Associations

Tissue Specificity

Widely expressed. Highly expressed in skeletal muscle. Expressed at intermediate level in brain, heart, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes. Weakly expressed in colon, thymus and small intestine. {ECO:0000269PubMed:12802337, ECO:0000269PubMed:16044242}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0042562	hormone binding
GO:0042802	identical protein binding
GO:0046982	protein heterodimerization activity
GO:0055100	adiponectin binding

Biological Process

GO:0009755	hormone-mediated signaling pathway
GO:0019395	fatty acid oxidation
GO:0030308	negative regulation of cell growth
GO:0033210	leptin-mediated signaling pathway
GO:0033211	adiponectin-activated signaling pathway
GO:0046427	positive regulation of JAK-STAT cascade
GO:0046628	positive regulation of insulin receptor signaling pathway